【Abstract】Objective To study the difference of telomerase activity in the common thyroid lesions . Methods The telomerase activity was detected in 19 patients with thyroid carcinomas, 15 samples adjacent to thyroid carcinomas，21 specimens of thyromas, 17 cases of nodular goiters and 13 pieces of normal thyroid tissues by telomeric repeat amplification protocol（TRAP). Results Eighteen of 19 samples of thyroid carcinoma, 1 of 15 samples adjacent to the cancer and 1 of 21 adenoma of the thyroid specimens showed positive telomerase activity, all 17 cases of nodular goiters and 18 samples of normal thyroid tissues exhibited negative telomerase activity, and the rate of positive telomerase activity of thyroid carcinomas was significantly higher than that of the other tissues (P＜0.0001). Conclusion The telomerase is an important qualitative marker of thyroid carcinoma and a useful index in differential diagnosis of thyroid lesions.
Citation：
WU Xinggui,QI Baoqing,SONG Yujun.. DETECTION OF TELOMERASE ACTIVITY IN THYROID LESION AND ITS SIGNIFICANCE. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(5): 313-314. doi:
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Koyanagi K, Ozawa S, Ando N, et al. Clinical significance of telomerase activity in noncancerous epithelial region of esophageal squamous cell carcinoma 〔Ｊ〕. Br J Surg， 1999； 86(5)∶ 674.
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Koyanagi K, Ozawa S, Ando N,et al. Telomerase activity as an indicator of malignant potential in iodinenonreactive lesions of the esophagus 〔Ｊ〕.Cancer，2000； 88(7)∶1524.
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- 1. Kim NW, Piatyszek MA, Prowae KR, et al. Specific association of human telomerase activity with immortal cells and cancer 〔Ｊ〕. Science， 1994； 266(5193)∶2011.
- 2. Hiyama E, Hiyama K, Yokoyama T, et al. Telomerase activity in smallcell and nonsmallcell lung cancers 〔Ｊ〕. J Natl Cancer Inst， 1995； 87(12)∶895.
- 3. Tahara H, Nakanishi T, Kitamoto M, et al. Telomerase activity in human liver tissues: comparison between chronic liver disease and hepatocellular carcinoma 〔Ｊ〕. Cancer Res， 1995； 55(13)∶2734.
- 4. Hiyama E, Gollahan L, Kataoka T, et al. Telomerase activity in human breast tumors 〔Ｊ〕. J Natl Cancer Inst， 1996； 88(2)∶116.
- 5. Langford LA, Piatyszek MA, Xu R, et al. Telomerase activity in human brain tumors 〔Ｊ〕. Lancet， 1995； 346(8985)∶1267.
- 6. Hiyama E, Youkyama T, Kuni N, et al. Telomerase activity in gastric cancer 〔Ｊ〕. Cancer Res， 1995； 55(15)∶3258.
- 7. Koyanagi K, Ozawa S, Ando N, et al. Clinical significance of telomerase activity in noncancerous epithelial region of esophageal squamous cell carcinoma 〔Ｊ〕. Br J Surg， 1999； 86(5)∶ 674.
- 8. Koyanagi K, Ozawa S, Ando N,et al. Telomerase activity as an indicator of malignant potential in iodinenonreactive lesions of the esophagus 〔Ｊ〕.Cancer，2000； 88(7)∶1524.
- 9. Hiyama E, Saeki T, Hiyama K, et al. Telomerase activity as a marker of breast carcinoma in fineneedle aspirated samples 〔Ｊ〕. Cancer， 2000； 90(4)∶ 2358.
