【Abstract】Objective To investigate the correlation of adhesive molecule expressions with potential of invasion and metastasis in papillary thyroid carcinoma (PTC). Methods S-P immunohistochemical method was used to detect CD44v6 and E-cadherin expression in 58 cases of PTC. Results The positive rates of CD44v6 and E-cadherin in PTC were 72.40%and 41.4% respectively. There was a positive correlation between CD44v6 expression and tumor invasive and metastatic potential in PTC (P＜0.05), and a reverse correlation between E-cadherin expression and the potential (P＜0.01).Moreover,there was a reverse correlation between the CD44v6 and E-cadherin expression in PTC(P＜0.05). Conclusion These data show a correlation between the adhesive molecule expression and the potential of invasion and metastasis in PTC. CD44v6 and E-cadherin may be prognostic indicators in PTC.
Citation：
LI Zinai,QIU Jianlong,WU Chunlin,et al.. ADHESIVE MOLECULE EXPRESSION IN RELATION TO INVASION AND METASTASIS IN THYROID PAPILLARY CARCINOMA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(5): 317-318. doi:
Copy
Copyright © the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
| 1. |
Ermak G,Jennings T,Robinson L,et al.Restricted pattern of CD44 variant exon expression in human papillary thyroid carcinoma 〔Ｊ〕. Cancer Res,1996; 56(5)∶1037.
|
| 2. |
Souka T,Salmi M,Joensun H, et al. Regulation of CD44v6 containing isoforms during proliferation of normal and malignant epithelial cells 〔Ｊ〕. Cancer Res,1997; 57(11)∶2281.
|
| 3. |
Gu J,Daa T,Kashima K,et al.Expression of splice variant of CD44 in thyroid neoplasms derived from follicular cells 〔Ｊ〕. Pathol Int,1998; 48(3)∶184.
|
| 4. |
Shiozaki H,Oka H, Inoue M, et al. Ecadherin mediated adhesion system in cancer cell 〔Ｊ〕. Cancer,1996; 77(9)∶1605.
|
| 5. |
姚灵，周信达．上皮型钙粘蛋白（Ecadherin）在癌侵袭转移中的作用 〔Ｊ〕．中国肿瘤临床，1997; 24(11)∶863.
|
- 1. Ermak G,Jennings T,Robinson L,et al.Restricted pattern of CD44 variant exon expression in human papillary thyroid carcinoma 〔Ｊ〕. Cancer Res,1996; 56(5)∶1037.
- 2. Souka T,Salmi M,Joensun H, et al. Regulation of CD44v6 containing isoforms during proliferation of normal and malignant epithelial cells 〔Ｊ〕. Cancer Res,1997; 57(11)∶2281.
- 3. Gu J,Daa T,Kashima K,et al.Expression of splice variant of CD44 in thyroid neoplasms derived from follicular cells 〔Ｊ〕. Pathol Int,1998; 48(3)∶184.
- 4. Shiozaki H,Oka H, Inoue M, et al. Ecadherin mediated adhesion system in cancer cell 〔Ｊ〕. Cancer,1996; 77(9)∶1605.
- 5. 姚灵，周信达．上皮型钙粘蛋白（Ecadherin）在癌侵袭转移中的作用 〔Ｊ〕．中国肿瘤临床，1997; 24(11)∶863.
