• Department of General Surgery, Second Affiliated Hospital, Suzhou University,Suzhou 215004;
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【Abstract】Objective  To introduce three methods of creating the animal model of bone metastasis from breast cancer and the advances in the application of these models. Methods  The related literatures were collected and reviewed.Results  In summary, breast cancer cells injected through left ventricles was commonly used. Breast cancer cells injected into medullary cavity of shaft of femur was simple and effective, but it was very different from the real condition of bone metastasis of patients. The development of animal model created by surgical orthotopic implantation gives the researchs an ideal instrument similar with the condition of patients to research the mechanism of bone metastasis and the treatment. Conclusion  Each animal model of bone metastasis from breast cancer has itself usefulness. Our destination is to create the real model of bone metastasis from breast cancer that is very similar with the patients.

Citation: JIANG Guoqin,ZHANG Zhide.. CREATION OF THE ANIMAL MODEL OF BONE METASTASIS OF BREAST CANCER. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(5): 355-357. doi: Copy