• Department of General Surgery, Sun Yat-sen Memorial Hospital, Zhongshan University of Medical Sciences, Guangzhou 510120;
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【Abstract】Objective  To study the mechanisms of enhancing effect of mild hypothermia (MH) to ischemic preconditioning (IP) on hepatic ischemiareperfusion (I-R) injury. Methods  To observe the content of the marker enzymes of liver damage (ALT,AST,LDH) and malondialdehyde (MDA), and activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPX), total antioxidase (TAX) in inferior vena cava blood above liver in nonischemic control group (n=6), I-R group (n=6), IP group (n=6) and mild hypothermic ischemic preconditioning (MHIP) group (n=6). Results  After I-R the content of ALT,AST, LDH and MDA were significantly elevated (P<0.01), SOD,CAT,GSH-PX,ACT activities were declined obviously (P<0.01). The content of ALT,AST,LDH and MDA were significantly lower in IP group than those in I-R group, and in MHIP group than those in IP group (P<0.01,P<0.05), and the content of SOD, CAT,GSH-PX, ACT activities were significantly higher in IP group than those in I-R group, and in MHIP group than those in IP group (P<0.01,P<0.05). Conclusion  Ischemic preconditioning may enhance the oxidation-resistance of liver, and reduce the oxygen free radical injury to liver after ischemia-reperfusion. Mild hypothermia may enhance the protective effect of IP on hepatic ischemiareperfusion injury.

Citation: HE Jinsong,ZHU Wenfeng,JIANG Lihua,et al.. ENHANCE EFFECT OF MILD HYPOTHERMIA TO ISCHEMIC PRECONDITIONING ON LIVER INJURY OF HEPATIC ISCHEMIAREPERFUSION. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(6): 370-372. doi: Copy