• Department of Vascular Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an 710033;
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【Abstract】Objective  To observe the changeable expressions of vascular endothelial growth factor (VEGF) and integrin β3 during the angiogenetic process of granulation tissue. Methods  mRNA and protein of VEGF and integrin β3 in human normal subcutaneous tissue, proliferative granulation tissue and mature granulation tissue were observed by RT-PCR and immunohistochemistry staining. Results  The expressions VEGF and integrin β3 were low in normal subcutaneous tissue and were much higher in proliferative granulation tissue. When the granulation tissue was mature, the expression was decreased again. Conclusion  VEGF and integrin β3 are important regulating factors in ngiogenesis.

Citation: ZHANG Juliang,WANG Ling,JIN Yuanchao,et al.. EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR AND INTEGRIN β3 DURING THE ANGIOGENETIC PROCESS OF GRANULATION TISSUE. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(6): 378-380. doi: Copy