THE CLINICAL SIGNIFICANCE OF MONITORING CARBOHYDRATE ANTIGEN CA50 IN PATIENTS WITH COLORECTAL CARCINOMA_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

Wang Kang , Liu Hao , Xu Yanfa.

Department of General Surgery， First Affiliated Hospital， Xian Medical University， Xian 710061;

Corresponding author：

Keywords：

Carbohydrate antigen CA50; Colorectal carcinoma; Diagnosis

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

In order to investigate the possible involvement of the antigen CA50 in patients with colorectal carcinoma， the carbohydrated antigen CA50 in serum was examined in 30 normal individual， 27 patients with benign colorectal diseases and 66 patients with colorectal carcinoma by immunoradiometric assay (IRMA). The results showed that the serum CA50 in patients with colorectal carcinoma was significantly higher than that in patients with benign colorectal diseases and normal individual (Ｐ＜0.01). It was significantly declined after radical operation (Ｐ＜0.01). However， no significant change was noted after palliative operation (Ｐ＞0.05) and elevation was noted in patients with tumor recurrence. The results suggest that the measurement of serum CA50 may be an useful marker for diagnosis and prognostic evaluation in patients with colorectal carcinoma.

Citation： Wang Kang,Liu Hao,Xu Yanfa.. THE CLINICAL SIGNIFICANCE OF MONITORING CARBOHYDRATE ANTIGEN CA50 IN PATIENTS WITH COLORECTAL CARCINOMA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(1): 24-25. doi: Copy

1.	Lindholm L, Holmgren J, Svennerholm L, et al. Monoclonal antibodies against gastrointestinal tumorassociated antigens isolated as monosialogangliosides. Int Arch Allergy Appl Immunol, 1983; 71(5)∶178.
2.	Holmgren J,Lindholm L, Pesson B, et al. Detection by monoclinal antibody of carbohydrate antigen CA50 in serum of patients with carcinoma. Br Med J, 1984; 288(19)∶1479.
3.	Hershman MJ, Habib NA, Ferro MA, et al. The use of CA50 radioimmunassay test in diagnosis of urologic malignancy.Am Surgeon, 1987; 53(9)∶691.
4.	张登学，张翠萍，徐向岚等. 血清糖链抗原50对胃癌的诊断价值. 肿瘤防治研究， 1995； 22(4)∶224.
5.	李长岭，许秉责，陈智周等. 肿瘤相关抗原CA50监测泌尿男生殖系统恶性肿瘤的临床意义. 中华肿瘤杂志， 1994； 16(2)∶148.
6.	王颖，叶秀，徐冰等. 血清CA50含量对消化系统肿瘤的诊断价值. 新消化病学杂志， 1997； 5(8)∶514.
7.	张登学，牟永善，郭英华等. 恶性肿瘤患者血清糖链抗原50的变化及其临床意义. 中华内科杂志， 1992； 31(12)∶766.

1. Lindholm L, Holmgren J, Svennerholm L, et al. Monoclonal antibodies against gastrointestinal tumorassociated antigens isolated as monosialogangliosides. Int Arch Allergy Appl Immunol, 1983; 71(5)∶178.
2. Holmgren J,Lindholm L, Pesson B, et al. Detection by monoclinal antibody of carbohydrate antigen CA50 in serum of patients with carcinoma. Br Med J, 1984; 288(19)∶1479.
3. Hershman MJ, Habib NA, Ferro MA, et al. The use of CA50 radioimmunassay test in diagnosis of urologic malignancy.Am Surgeon, 1987; 53(9)∶691.
4. 张登学，张翠萍，徐向岚等. 血清糖链抗原50对胃癌的诊断价值. 肿瘤防治研究， 1995； 22(4)∶224.
5. 李长岭，许秉责，陈智周等. 肿瘤相关抗原CA50监测泌尿男生殖系统恶性肿瘤的临床意义. 中华肿瘤杂志， 1994； 16(2)∶148.
6. 王颖，叶秀，徐冰等. 血清CA50含量对消化系统肿瘤的诊断价值. 新消化病学杂志， 1997； 5(8)∶514.
7. 张登学，牟永善，郭英华等. 恶性肿瘤患者血清糖链抗原50的变化及其临床意义. 中华内科杂志， 1992； 31(12)∶766.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

THE CLINICAL SIGNIFICANCE OF MONITORING CARBOHYDRATE ANTIGEN CA50 IN PATIENTS WITH COLORECTAL CARCINOMA

Abstract Full text Figures/Tables Video References Cited by

Format

Content