AN EXPERIMENTAL STUDY ON PERMEABILITY OF ANTIBIOTICS TO PANCREATIC TISSUE_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of General Surgery, First Affiliated Hospital, West China University of Medical Scicences, Chengdu 610041;

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Keywords：

Pancreatitis; Therapy; Antibiotics; Pancreatic tissue; Permeability

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In order to choose the appropriate antibiotics for treating secondary pancreatic infection, permeability of antibiotics to pancreatic tissue was investigated on experimental dogs with acute hemorrhagic necrotizing pancreatitis. The concentrations of 8 different antibiotics were determined in the blood and the pancreatic tissue using highperformance liquid chromatography. Pancreatic tissue permeability of Cefotaxime, Ofloxacin, Amikacin, Piperacllin, Cefoperazone, Ampicillin, Metronidazole and Ciprofloxacin was 12%, 19%, 20%, 46%, 55%, 63%, 71% and 132% respectively. The study shows that this eight antibiotics have different permeability to the pancreatic tissue. Such observations support the existence of a bloodpancreas barrier, which acts to restrict the permeation of antibiotics into the pancreas. The results suggest that antibiotics with high permeability rate be used to treat the patient with secondary pancreatic infection.

Citation： Yao Yougui,Lin Qiyuan,Jiang Lisheng,et al.. AN EXPERIMENTAL STUDY ON PERMEABILITY OF ANTIBIOTICS TO PANCREATIC TISSUE. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(2): 76-78. doi: Copy

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1. Widdison AL, Karanjia ND. Pancreatic infection complicating acute pancreatitis. Br J Surg, 1993; 80(3)∶148.
2. Widdison AL, Karanjia ND, Reber HA. Antimicrobial treatment of pancreatic infection in cats. Br J Surg, 1994; 81(3)∶886.
3. Pederzoli P, Bassi C, Vesentini S, et al. Antibiotics in acute pancreatitis: the debate revistited. Am J Gastroenterology, 1995; 90(4)∶666.
4. Buchler M, Malfertheiner P, Freiss H, et al. Human pancreatic tissue concentration of bactericidal antibiotics. Gastroenterology, 1992; 103(6)∶1902.
5. Burns GP, Stein TA, Kabnick LK. Bloodpancreatic juice barrier to antibiotic excretion. Am J Surg, 1986; 151(2)∶205.
6. Tyden G, Malmobrg AS. Penetration of antibiotics into pancreatic juice. Lancet, 1985; 1∶1046.
7. Brattstrom C. Malmborg AS, Tyden G. Penetration of clindamycin, cefoxitin, and piperacillin into pancreatic juice in man. Surgery, 1988; 103(5)∶563.
8. Pederzoli P, Falconi M, Bassi C, et al. Ciprofloxacin penetration in pancreatic juice. Chemotherapy, 1987; 33(5)∶397.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

AN EXPERIMENTAL STUDY ON PERMEABILITY OF ANTIBIOTICS TO PANCREATIC TISSUE

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