THE EXPRESSION AND SIGNIFICANCE OF P21, P53, BCL-2 ONCOPROTEIN IN GALLBLADDER CARCINOMA_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

Chen Jingsong ¹ , Xiong Shouzhi ² , Yang Zhulin. ²

Department of Hepatobiliary Surgery, The People’s Hospital of Hainan Province, Haikou 570311;

Corresponding author：

Keywords：

Gallbladder carcinoma; Gallbladder adenomous polyp; Immunohistochemistry; Oncoprotein

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

The expression of p21, p53, bcl-2 oncoprotein was evaluated using immunohistochemistry in 40 patients with gallbladder carcinoma and 8 patients with gallbladder adenomous polyp. In the study, the positive rate of expression of p21, p53 and bcl-2 oncoprotein was 52.5%, 52.5% and 70.0% respectively in gallbladder carcinoma, while, in gallbladder polyp, they were 0%, 0% and 100% respectively. The positive rate of expression of p53 oncoprotein was significantly higher in poor-differentiated adenocarcinomas than in well-differentiated ones (Ｐ＜0.05). The converse was true for bcl-2 oncoprotein. The positive rate of expression of p21 and p53 oncoprotein was significantly higher in metastatic group than in non-metastatic one. These results suggest that the patients with the expression of p21, p53 might be of poor-prognosis.

Citation： Chen Jingsong,Xiong Shouzhi,Yang Zhulin.. THE EXPRESSION AND SIGNIFICANCE OF P21, P53, BCL-2 ONCOPROTEIN IN GALLBLADDER CARCINOMA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(2): 83-85. doi: Copy

1.	Kamel D, Puakkd P, Nuorva K, et al. p53 and CerbB protein expression in adenocarcinomas and ipithelial dysplasias of the gallbladder. J Pathol, 1993; 107(1)∶67.
2.	Jansson DS, Radosevich JA, Carney WE, et al. An immunohistochemical analysis of ras oncogene expression in epithelial neoplasms of colon. Cancer, 1990; 65(2)∶1329.
3.	Pilotl S, Collinni P, Rillke F, et al. Bcl2 protein expression in carcinomas originating from the follicular epitheliun of the tyroid gland. J Pathol, 1994; 72(1)∶337.
4.	Masakiko Y, Takahiro F, Baisuke A, et al.Expression of oncogene products and growth factors in early gallbladder cancer, advanced gallbladder cancer and chronic cholecystitis. Hum Pathol, 1993; 24(4)∶37.
5.	Wee A, The M, Raju GC, et al. Clinical importance of p53 protein in gallbladder carcinoma and its precursor lesions. J Clin Pathol, 1994; 47(2)∶453.
6.	Dia K, Doglioni C, Lourinol, et al. P53 and cerb B2 protein expression in adenocarcinomas and epithelial dysplasia of the gallbladder. J Pathol, 1993; 170(4)∶67.
7.	Rasbridge SA, Gillett CE, Symour AM, et al. The effect of che-motherapy on morpholohy, cellular proliferation aptosis and oncoprotein expression in primary breast carcinoma. Cancer, 1994; 70(1)∶335.
8.	江希明，郑树，丁仁瑞. 肿瘤生物学. 第1版. 杭州：浙江科学技术出版社， 1990∶92～135.

1. Kamel D, Puakkd P, Nuorva K, et al. p53 and CerbB protein expression in adenocarcinomas and ipithelial dysplasias of the gallbladder. J Pathol, 1993; 107(1)∶67.
2. Jansson DS, Radosevich JA, Carney WE, et al. An immunohistochemical analysis of ras oncogene expression in epithelial neoplasms of colon. Cancer, 1990; 65(2)∶1329.
3. Pilotl S, Collinni P, Rillke F, et al. Bcl2 protein expression in carcinomas originating from the follicular epitheliun of the tyroid gland. J Pathol, 1994; 72(1)∶337.
4. Masakiko Y, Takahiro F, Baisuke A, et al.Expression of oncogene products and growth factors in early gallbladder cancer, advanced gallbladder cancer and chronic cholecystitis. Hum Pathol, 1993; 24(4)∶37.
5. Wee A, The M, Raju GC, et al. Clinical importance of p53 protein in gallbladder carcinoma and its precursor lesions. J Clin Pathol, 1994; 47(2)∶453.
6. Dia K, Doglioni C, Lourinol, et al. P53 and cerb B2 protein expression in adenocarcinomas and epithelial dysplasia of the gallbladder. J Pathol, 1993; 170(4)∶67.
7. Rasbridge SA, Gillett CE, Symour AM, et al. The effect of che-motherapy on morpholohy, cellular proliferation aptosis and oncoprotein expression in primary breast carcinoma. Cancer, 1994; 70(1)∶335.
8. 江希明，郑树，丁仁瑞. 肿瘤生物学. 第1版. 杭州：浙江科学技术出版社， 1990∶92～135.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

THE EXPRESSION AND SIGNIFICANCE OF P21, P53, BCL-2 ONCOPROTEIN IN GALLBLADDER CARCINOMA

Abstract Full text Figures/Tables Video References Cited by

Format

Content