The expression of bcl-2 and p16 in 25 cases of gallbladder mucosa hyperplasia, 40 cases of gallbladder carcinoma and 25 adjacent normal gallbladder mucosa tissue was detected with immunohistochemical staining. Normal gallbladder mucosa was uniformly negative. Bcl-2 and p16 positive rate were significantly higher in hyperplasia and carcinoma than in normal tissue (Ｐ＜0.01). Expression of bcl-2 and p16 got higher with the increasing degree of hyperplasia, p16 was associated with lymph node metastasis and depth of invasion of carcinoma of the gallbladder. The results suggest that bcl-2 and p16 expression play an important role in tumorigenesis, p16 can be used as a prognostic index for gallbladder carcinoma.
Citation：
Zeng Siwu,Liu Yu,Liang Fenhua,et al.. EXPRESSION OF BCL-2 AND P16 PROTEIN AND THEIR SIGNIFICANCE IN GALLBLADDER BENIGN AND MALIGNANT LESION. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(2): 86-87. doi:
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- 1. Caulard P, Agay MF, Peuchmaur M, et al. Expression of bcl2 gene product in follicular lymphoma. Am J Pathol, 1991; 140(11)∶1089.
- 2. Pezzella F, Tse AG, Cordell JL, et al. Expression of the bcl2 oncogene protein is not specific for the 14∶18 chromosomal translocation. Am J Pathol, 1990; 137(3)∶225.
- 3. Koich E, Masshiro K, Shinichi K, et al. Amplifited bcl2 rearrangements in reactive lymphadenopathy. Virchows Archiv (Cell Pathol), 1992; 63(2)∶197.
- 4. 生秀杰， 宋和存， 何秀琴. 抗凋亡基因bcl2在子宫内膜癌的表达和意义. 中华肿瘤杂志， 1998； 20(5)∶365.
