To study the effects of arginine supplementation in total parenteral nutrition (TPN) on lymphocytic immune function in postoperative patients with gastric cancer. Thirty six patients with gastric cancer receiving TPN were eligible for entry into randomized and prospective clinical trial of the study. T cell subsets, NK cell activity, plasma IL-2 content and peripheral blood CD25 were measured in before and after parenteral nutrition of the patients. Results: usual TPN could not improve lymphocytic immunosuppression of postoperative patients with gastric cancer. The patients receiving arginine supplementation in TPN might enhance lymphocytic immune function by increasing CD4 level, IL-2 production and NK cell activity, but there was no significant effect of arginine on CD25 expression. Conclusion: there are some effects of supplement with arginine on releasing of the cellular immunosuppression and restoring of lymphocytic immune function.
Citation：
Wang Qi,Wang Jifu,Peng Junsheng.. THE EFFECTS OF ARGININE SUPPLEMENTATION IN TOTAL PARENTERAL NUTRITION ON LYMPHOCYTIC IMMUNE FUNCTION IN POSTOPERATIVE PATIENTS WITH GASTRIC CANCER. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(2): 100-103. doi:
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Copyright © the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
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- 1. 王新江， 陆华， 谷漱燕. 用MTT比色法检测人NK细胞活性. 中华实验和临床病毒学杂志， 1992； 6(1)∶69.
- 2. Daly JM, Reynolds J, Thom A, et al. Immune and metabolic effects of arginine in the surgical patient. Ann Surg, 1988; 208(4)∶512.
- 3. 曹艳英， 杨晓梅， 周正任等. 原发性肝癌病人手术前后NK活性、IL2产生能力、sIL2R表达水平的动态实验研究. 中华肿瘤杂志， 1993； 5(2)∶111.
- 4. 王颀， 王吉甫， 彭俊生. 两种脂肪乳剂对胃癌术后病人淋巴细胞免疫功能的影响. 现代临床普通外科杂志， 1996； 1(3)∶150.
- 5. 张利华， 黎介寿. 全肠外营养及免疫调节剂对腹腔感染大鼠免疫功能的调节. 中华实验外科杂志， 1994； 11(4)∶240.
- 6. Sedman PC, Ramsden CW, Brennan TG, et al. Effects of low perioperative interferon on the surgically induced suppression of antitumour immune responses. Br J Surg, 1988; 75(9)∶976.
- 7. Madden HP, Breslin RJ, Wasserkerug HL, et al. Stimulation of cell immunity by arginine enhances survival in peritonitis. J Surg Res, 1988; 44(6)∶658.
- 8. Reynolds JV, Daly JM, Shou J, et al. Immunologic effects of arginine supplementation in tumorbearing and nontumorbearing hosts. Ann Surg, 1990; 211(2)∶202.
- 9. Liebberman MD, Nishidka K, Redmond P, et al. Enhancement of interleukin2 immunotherapy with Larginine. Ann Surg, 1992; 215(2)∶157.
- 10. Grossie VB, Nishioka K, Ajan JA, et al. Substitating ornithine for arginine in total parenteral nutrition eliminates enhanced tumor growth. J Surg Oncol, 1992; 50(2)∶161.
- 11. 王颀， 王吉甫， 彭俊生. 不同脂肪乳剂对人淋巴细胞产生白介素2能力和膜受体表达影响的研究. 中华实验外科杂志， 1997； 14(增刊)∶153.
- 12. Brittenden J, Park KGM, Hayes PD, et al. Effect of arginine on natural cytotoxicity in cancer patients and healthy volunteers. Br J Surg, 1992; 79(5)∶442.
