EFFECT OF INTRAPERITONEAL HYPERTHERMO-CHEMOTHERAPY ON T-LYMPHOCYTE SUBSETS AND sIL2R LEVEL IN PATIENTS WITH GASTROINTESTINAL MALIGNANCY TUMOR_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

Ran Jianghua , Zhang Jiahua , Guo Qun , et al.

Department of General Surgery, The Second Affiliated Hospital of Kunming Medical College, Kunming 650101;

Corresponding author：

Keywords：

Intraperitoneal hyperthermo-chemotherapy; Gastrointestinal malignant tumor; T-lymphocyte subsetsInterleukin-2 receptor

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To evaluate the effect of intraperitoneal hyperthermo-chemotherapy (IPHC) on immunologic function of patients with gastrointestinal malignant tumor (GMT). The authors determined the serum T-lymphocyte subsets (T-LS) and interleukin-2 receptor (sIL-2R) of 32 patients with GMT after IPHC, and compared the two indexes with 20 healthy control group. Results: Before IPHC the serum CD＋3, CD＋4, CD＋8 and CD＋4/CD＋8 were higher and sIL-2R were lower than control group, after IPHC, CD＋3, CD＋4, CD＋8 and CD＋4/CD＋8 increased obviously (Ｐ＜0.01) and the serum sIL-2R decreased significantly (Ｐ＜0.01). Conclusion: The IPHC can improve the patients immunologic function.

Citation： Ran Jianghua,Zhang Jiahua,Guo Qun,et al.. EFFECT OF INTRAPERITONEAL HYPERTHERMO-CHEMOTHERAPY ON T-LYMPHOCYTE SUBSETS AND sIL2R LEVEL IN PATIENTS WITH GASTROINTESTINAL MALIGNANCY TUMOR. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(3): 156-157. doi: Copy

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1. 陈军，林言箴，尹治然. 进展期胃肠道恶性肿瘤术后早期腹腔内化疗. 癌症， 1994； 13(3)∶271.
2. 孙念绪，蔡志民. 进展期大肠癌术后早期腹腔灌洗化疗. 中华肿瘤杂志， 1998； 20(3)∶222.
3. Taradi M, Urano M, Taradi SK, et al. Augmentation of mouse natural killer cell activity by combined hyperthermi and streptococcul preparation, OK432 (Picibanil) treatment. Int J Hyperthermia, 1991; 7(4)∶653.
4. 王娟，宋志杰，刘怀深等. 胃癌术前卡铂腹腔化疗肿瘤组织浓度测定及药物动力学研究. 中国肿瘤临床， 1998； 25(4)∶261.
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6. Lotze MT, Finn OJ. Recent advances in cellular immunology: inplications for immunity to cancer. Immunol Today, 1990; 11(6)∶190.
7. Laurencea A, Rucin MD, David L, et al. The soluble interleukin2 receptor biology, function and clinical application. Ann Intern Med, 1990; 113(8)∶619.
8. 陈垦，汤斌，官成浓等. 胃癌病人血清sIL2R水平与红细胞免疫功能的相关性研究. 实用癌症杂志， 1996； 11(2)∶98.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

EFFECT OF INTRAPERITONEAL HYPERTHERMO-CHEMOTHERAPY ON T-LYMPHOCYTE SUBSETS AND sIL2R LEVEL IN PATIENTS WITH GASTROINTESTINAL MALIGNANCY TUMOR

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