To investigate the effect of intracellular glycogen on liver ischemia-reperfusion and its mechanism, histomorphological and enzymological changes, histic ATP contents, the activity of Ca2+-ATPase on cytoplasmic membrane and intracellular free Ca2+concentration were observed during the ischemia-reperfusion of three groups of rabbit livers with different glycogen content. We found that the more vigorous energy metabolism, the higher activity of Ca2+-ATPase, the lower concentration of intracellular free Ca2+ and the slighter injury of histic structure and function appeared in the liver with the more abundant glycogen. The results suggest that intracellular abundant glycogen may reduce liver ischemiareperfusion injury.
Citation：
Tang Lijun,Tian Fuzhou,Wang Yu,et al.. EFFECT OF INTRACELLULAR GLYCOGEN ON LIVER ISCHEMIA-REPERFUSION AND ITS MECHANISM. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(4): 196-198. doi:
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- 1. Cywes R, Greig PD, Morgan GR, et al. Rapid donor liver nutritional enhancement in a large animal model. Hepatology, 1992; 16(5)∶1271.
- 2. Astarcioglu I, Adam R, Gigou M, et al. High levels of glycogen in the donor liver improve survival after liver transplantation in rats. Transplant Proc, 1991; 23(5)∶2465.
- 3. Wolf RFE, Hoeven JAB, Kamman RL, et al. Tissue pH in cold stored human donor livers preserved in university of wisconsin solution. Transplantation, 1996; 61(1)∶66.
- 4. Cywes R, Paul CB, Juan R, et al. Effect of intrapartal glucose on hepatic glycogen content and degradation, and outcome of liver transplantation. Ann Surg, 1992; 216(3)∶235.
- 5. Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem, 1985; 260(9)∶3440.
- 6. 汤礼军， 田伏洲. 肝脏缺血再灌注损伤介质的研究现况. 肝胆外科杂志， 1998； 6(5)∶318.
