DETERMINATIONOFLEVELSOFCELLULARIMMUNITYANDHUMORALIMMUNITYINPATIENTSWITHGALLBLADDERCARCINOMA_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

JiaoXinyuan ¹ , ShiJingsen ¹ , GaoJinsong ² , etal. ¹

HepatobiliaryResearchLab,FirstAffiliatedHospitalofXi’anMedicalUniversity,Xi’an710061;

Corresponding author：

Keywords：

Gallbladdercarcinoma; Cellularimmunity; Humoralimmunity

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SerumIgG,IgA,IgM,C3andC4weredeterminedbyneophelmetricimmunoassay,serumandbiliaryIL2,sIL2Rlevelsweremeasuredbyatwoantibodysandwichenzymelinkedimmunosorbentassayinpatientswithsimplegallbladdercarcinoma,withbothgallbladdercarcinomaandgallstone,withsimplegallstoneandhealthyindividuals.Theresultsshowedthat:①Comparedwithcontrols,thegallbladdercarcinomapatientshadobviouslyloweredserumandbiliarylevelsofIL2andCD+4cell;andtheypresentedamarkedincreasedserum,biliarylevelsofsIL2RandCD+8cell.②TherewascorrelationbetweenthelevelsofsIL2RandCD+8,IL2andCD+4inthepatientswithgallbladdercarcinomaandtheirclinicstage.③Comparedwiththepatientswithgallbladdercarcinoma,gallstonepatientspresentedamarkeddecreasedserumandbiliarylevelofsIl2RandCD+8cell,andamarkedincreasedserumandbiliarylevelofIL2andCD+4cell.Theresultssuggestthat:①Thepatientswithgallbladdercarcinomahaveimmunedepression;②Inthepatientswithgallbladdercarcinomaandgallstone,gallstoneasainjuryfactorbrokethebalancebetweenCD+4andCD+8,thebalancebetweenIL2anditsreceptor;③TcellsubpopulationandsIL2R,IL2levelsmaybeusedasmarkerstopredictthechangesinpatientswithgallbladdercarcinoma.

Citation： JiaoXinyuan,ShiJingsen,GaoJinsong,etal.. DETERMINATIONOFLEVELSOFCELLULARIMMUNITYANDHUMORALIMMUNITYINPATIENTSWITHGALLBLADDERCARCINOMA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(4): 227-229. doi: Copy

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2. LeeWJ,ChangKJ,LeeCS,etal.SelectdepressionofTlymphocytesubsetsingastriccancerpatients:animplicationofimmunotherapy.JSurgOncol,1994;55(3)∶165.
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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

DETERMINATIONOFLEVELSOFCELLULARIMMUNITYANDHUMORALIMMUNITYINPATIENTSWITHGALLBLADDERCARCINOMA

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