DISTRIBUTION OF 125I-LABELED 17α-VINYLESTRADIOL-3-ACETATE IN NUDE MICE BEARING HUMAN BREAST CANCER_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

Department of General Surgery, First Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041;

Corresponding author：

Keywords：

Breast cancer; Estrogen receptor; Estrogen receptor tracer; Estrogen receptor imaging

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Biodistribution of125I-labeled 17α-vinyestradiol-3-acetate (125I-VE2A)in nude mice bearing human breast cancer containing different estrogen receptor (ER) content was studied to understand the relation between this compound and ER and, consequently, to develop the ER imaging. Each mouse was injected with 92.5 kBq tracer from tail vein and then killed after two hours. The radioactivity uptake rate in one gram of tumor tissue and tissues from other vital organs were measured, and the radioactivity uptake ratio of tumor to nontumor tissue was also measured. Results: The radioactivity uptake rate and the radioactivity uptake ratio of tumor to nontumor tissue in ER positive tumor (MCF-7) were much higher than those in ER negative tumor (MDA-MB-231). Conclusions: This compound, IVE2A has affinity to ER positive target organ or tumor and promise the probability to define the content and site of ER in vivo or in tumor.

Citation： Long Qiming,Yang Jinqiao,Chen Xiaoli,et al.. DISTRIBUTION OF 125I-LABELED 17α-VINYLESTRADIOL-3-ACETATE IN NUDE MICE BEARING HUMAN BREAST CANCER. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(5): 266-267. doi: Copy

1.	Joan HM. Hormone receptors and breast cancer. Human Pathol, 1981; 12(12)∶1057.
2.	Nakatsuka I, Ferreira NL, Eckelman WC, et al. Synthesis and evaluation of (17α， 20E)21〔125I〕iodo19norpregna1,3,5(10), 20tetraene3, 17diol and (17α, 20E)21〔125I〕iodo11βmethoxy19norpregna1,3,5(10), 20tetraene3, 17diol 17α(iodovingl) estradiol derivatives as high specific activity potential radiopharmaceuticals. J Med Chem, 1984; 27(10)∶1287.
3.	Eckelman WC, Reba RC, Gibson RE, et al. Receptor binding radiotracers: a class of potential radiopharmaceuticals. J Nucl Med, 1979; 20(2)∶350.
4.	EU PJ, Khan O. Emission computerised tomography: clinical application. Semi in Nucl Med, 1981; 11(1)∶50.
5.	Cummins CH. Radiolabeled steroid estrogens in cancer research. Steroid, 1993; 58(2)∶245.
6.	Symes EK, Bishop PB, Coulson WF, et al. 17αZ〔125I〕 iodovingloestradiol and its 3acetate: chemical synthesis and in vivo distribution studies in the rat. Biochem Parmacol, 1992; 44(4)∶741.
7.	Zeicher M, Delcorde A, Quivy J, et al. Radioimaging of human breast carcinoma xenografts in mice by 〔123I〕lebeled Z17αiodovingl11βchloromethy estradiol. Nucl Med Biol, 1996; 23(1)∶69.
8.	McManaway ME, Jagodo EM, Kasid A, et al. 〔125I〕17αiodovingl 11βmethoxyestradiol interaction in vivo with estrogen receptors in hormoneindependent MCF7 human breast cancer transfected with the VrasH oncogene. Cancer Res, 1987; 47(11)∶2945.

1. Joan HM. Hormone receptors and breast cancer. Human Pathol, 1981; 12(12)∶1057.
2. Nakatsuka I, Ferreira NL, Eckelman WC, et al. Synthesis and evaluation of (17α， 20E)21〔125I〕iodo19norpregna1,3,5(10), 20tetraene3, 17diol and (17α, 20E)21〔125I〕iodo11βmethoxy19norpregna1,3,5(10), 20tetraene3, 17diol 17α(iodovingl) estradiol derivatives as high specific activity potential radiopharmaceuticals. J Med Chem, 1984; 27(10)∶1287.
3. Eckelman WC, Reba RC, Gibson RE, et al. Receptor binding radiotracers: a class of potential radiopharmaceuticals. J Nucl Med, 1979; 20(2)∶350.
4. EU PJ, Khan O. Emission computerised tomography: clinical application. Semi in Nucl Med, 1981; 11(1)∶50.
5. Cummins CH. Radiolabeled steroid estrogens in cancer research. Steroid, 1993; 58(2)∶245.
6. Symes EK, Bishop PB, Coulson WF, et al. 17αZ〔125I〕 iodovingloestradiol and its 3acetate: chemical synthesis and in vivo distribution studies in the rat. Biochem Parmacol, 1992; 44(4)∶741.
7. Zeicher M, Delcorde A, Quivy J, et al. Radioimaging of human breast carcinoma xenografts in mice by 〔123I〕lebeled Z17αiodovingl11βchloromethy estradiol. Nucl Med Biol, 1996; 23(1)∶69.
8. McManaway ME, Jagodo EM, Kasid A, et al. 〔125I〕17αiodovingl 11βmethoxyestradiol interaction in vivo with estrogen receptors in hormoneindependent MCF7 human breast cancer transfected with the VrasH oncogene. Cancer Res, 1987; 47(11)∶2945.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

DISTRIBUTION OF 125I-LABELED 17α-VINYLESTRADIOL-3-ACETATE IN NUDE MICE BEARING HUMAN BREAST CANCER

Abstract Full text Figures/Tables Video References Cited by

Format

Content