In this study, the role of newcastle disease virus (NDV) combined thermic solidified tumor vaccine in inhibiting growth of tumor and immune control was investigated, and rate of inhibiting tumor and cellular immunity were measured. The results showed that rate of inhibiting tumor in experimental group Ⅰ and Ⅱ were 24.8% and 41.1% respectively; average weight of tumor was significantly lower in both experimental groups than in control group, and activity of natural killing (NK) cells in experimental groups was higher than that in control group (Ｐ＜0.01). This suggests that NDV combined thermic solidified tumor vaccine can inhibit growth of tumor and improve activity of NK cells, and their effects are better than that of NDV.
Citation：
Li Xiaojun,Bai Yanting,Tian Fuzhou,et al.. STUDY ON ANTITUMOR ROLE OF NEWCASTLE DISEASE VIRUS COMBINED THERMIC SOLIDIFIED TUMOR VACCINE IN RATS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(5): 276-277. doi:
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- 1. Flangan AD, Love R, Tesar W. Propagation of newcastle disease virus in ehrlic ascies cells in vitro and in vivo. Proc Soc Exp Biol Med, 1955; 90(4)∶82.
- 2. 黄祯祥， 张礼碧， 贾风兰等. 病毒治疗小鼠腹水瘤作用的研究. 中华肿瘤杂志， 1985； 7(5)∶332.
- 3. Cassel WA, Garett RE. Newcastle disease virus as an antineoplastic. Cancer, 1965; 18(3)∶863.
- 4. 刘晓波， 田伏洲， 李小军等. 热处理小鼠H22肝癌细胞的抗肿瘤作用. 中华物理医学杂志， 1997； 19(2)∶78.
- 5. 曲增强， 吴孟超， 陈汉等. 新城疫病毒瘤苗对荷瘤小鼠的主动免疫治疗作用. 实用癌症杂志， 1996； 11(2)∶73.
- 6. Reichard KW, Lorence RM, Cascino J, et al. Newcastle disease virus selectively kills human tomor cells. J Surg Res, 1992; 52(6)∶448.
