• Department of Surgery, The General Hospital of Shengyang Military Area, Shengyang 110015;
β-glucuronidase; Bilirubin stone; Hepatic cell
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To study the relationship between the activity of endogenous β-glucuronidase (β-G) in hepatic tissue and the formation of bilirubin stone. We assessed the β-G activity in hepatic tissue of 44 cases of bilirubin stone, 8 cases of cholesterol stone and 25 cases of liver injury by using immunohistochemistry. Results: The cell percentage of β-G positive reaction in bilirubin stone group (49.2%±4.6%) was significantly higher than those in cholesterol stone group (32.5%±3.8%) and liver injury group (27.8%±4.2%), Ｐ＜0.05. There was no relationship between cell percentage of β-G positive reaction and age, patient history, size of stone. Conclusions: The activity of endogenous β-G is closely related to the formation of bilirubin stone. The difference of activity between individuals is possibly the intrinsic factor which may influence the formation of bilirubin stone.

Citation： Yang Bo,Zhu Shande,Zhao Yongguang,et al.. STUDY ON THE RELATIONSHIP BETWEEN THE ACTIVITY OF ENDOGENOUS β-GLUCURONIDASE IN HEPATIC TISSUE AND BILIRUBIN STONE. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(5): 278-279. doi: Copy