CLINICAL SIGNIFICANCE OF SERUM THYROTROPIN RECEPTOR ANTIBODY IN GRAVE′S DISEASE (REPORT OF 156 CASES)_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of General Surgery, First Affiliated Hospital of West China University of Medical Sciences, Chengdu 610041;

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Keywords：

Crave′s disease; Thyrotropin receptor antibody; Diagnosis; Treatmen

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To study the relationship between the level of serum thyrotropin receptor antibody (TRAb) and the severity of Crave′s disease. From August, 1996 to June, 1998, 156 outpatients with Crave′s disease were followed up. The level of serum TRAb were measured by radio-receptor-analysis (RRA). Results: ①The level of serum TRAb rose in 90.1% of the untreated group; ②The level of serum TRAb restored to normal after the antithyroid drugs were used and the thyroxine level in serum returned to normal; ③In recurrent patients with the treatment of131I, drugs or operation, the serum TRAb level increased. Conclusion: The level of serum TRAb has great significance in the diagnosis, treatment and follow up of the Crave′s disease.

Citation： Xu Huizhen,Li Yuan,Shen Bin et al.. CLINICAL SIGNIFICANCE OF SERUM THYROTROPIN RECEPTOR ANTIBODY IN GRAVE′S DISEASE (REPORT OF 156 CASES). CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(5): 280-282. doi: Copy

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1. Skuza KA, Sills IN, Stene M, et al. Prediction of neonatal hyperthyroidism in infants born to mothers with Grave′s disease. J Pediatr, 1996; 128(2)∶264.
2. Resch B, Mache C, Rosegger H, et al. Neonatal hyperthyroidism caused by TSH receptor antibodies in materal autoimmune hyperthyroidism. Z Geburtshilfe Neonatol, 1995 199(6)∶248.
3. Roth C,Siggelkow H, Gruters A, et al. Neonatal Basedow′s disease in twins from a mother with sevee T3 hyperthyroidism. Dtsch Med Wochenschr, 1997; 122(16)∶572.
4. Ahmed K, Tomiyoshi K, Fukazawa K, et al. Measurement of serum TSH receptor antibody in thyriod patients using TRAb dade kits. Kaku Igaku, 1995; 32(1)∶695.
5. James B. Wyngaardem, Lloyd H. Smith Jr, J. Claude Bennett, et al. Cecil textbook of medicine. 19th edition. Philadelphia: W.B. Saunders Company, 1992∶1254.
6. Hirsch C, Spyra JL, Langhammer HR, et al. Occurrence of immune hyperthyroidism after radioiodeme therapy of autonomous goiter. Med Klin, 1997; 92(3)∶130.
7. Takai Y. Clinical evaluations of subtotal thyroidectomy for Grave′s disease. Nippon Naibunpi Gakkai Zasshi, 1995; 71(1)∶27.
8. Sugino K, Mimura T, Ozaki O, et al. Preoperative change of thyroid stimulating hormone receptor antibody level: possible marker for predicting recurrent hyperthyroidism in patient with Grave′s disease after subtotal thyroidectomy. World J Surg, 1996; 20(7)∶801.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

CLINICAL SIGNIFICANCE OF SERUM THYROTROPIN RECEPTOR ANTIBODY IN GRAVE′S DISEASE (REPORT OF 156 CASES)

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