ANALYSIS OF TUMOR ANGIOGENESIS IN BREAST CARCINOMA AND BENIGN BREAST DISEASE_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of General Surgery, First Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041;

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Keywords：

Breast carcinoma; Microvessel density; Angiogenesis

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This study was designed to define the microvessel density (MVD) in breast carcinoma and benign breast disease and the relationship of microvessel density with the tumor size, histologic grade, and lymph node status. Under light microscopy, the microvessels by staining their endothelial cells immunocytochemically for factor Ⅷ were highlighted. Results: The mean level of MVD of breast carcinoma was significantly higher than that of benign disease (Ｐ＜0.01); the MVD of breast carcinoma was associated with tumor size (Ｐ＜0.05), histologic grade (Ｐ＜0.05), and axillary node status (Ｐ＜0.05), but no association with estrogen receptor. These show that MVD of breast carcinoma is significantly higher than that of benign breast disease, and MVD of breast carcinoma is one of significant prognostic indicators.

Citation： Li Hongjiang,Jing Jing,Zhu Jingqiang,et al.. ANALYSIS OF TUMOR ANGIOGENESIS IN BREAST CARCINOMA AND BENIGN BREAST DISEASE. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(5): 285-287. doi: Copy

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1. 李宏江，朱精强. 乳癌中微血管活性检测的意义. 国外医学·外科学分册， 1998； (6)∶344.
2. Algire GH, Chalkley HW, Legallais FY, et al. Vascular reactions of normal and malignant tumors in vivo. I. Vascular reactions in mice to wounds and to normal and neoplastic transplants. J Natl Cancer Inst, 1945; 25(6)∶73.
3. Folkman J. Introduction: angiogenesis and cancer. Semin Cancer Biol, 1992; 84(3)∶47.
4. Gimbrone MA Jr, Gullino PM. Neovascularization induced by introcular xenografts of normal, preneoplastic, and neoplastic mouse mammary tissues. J Natl Cancer Inst, 1976; 56(2)∶305.
5. Guinerbretiere JM, Le Monique G, Gavoille A, et al. Angiogenesis and risk of breast cancer in women with fibrocystic disease. J Natl Cancer Inst, 1994; 86(8)∶635.
6. Brem SS, Gullino PM, Medina D. Angiogenesis: a marker for neoplastic transformation of mammary papillary hyperplasia. Science, 1977; 195(38)∶880.
7. Horak ER, Leek R, Klenk N, et al. Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastasis and survival in breast cancer. Lancet, 1992; 340(8828)∶1120.
8. Da Silva ID, De Lima GR, Gebrim LH, et al. Invasive ductal carcinoma, fibroadenoma and adjacent breast stroma angiogenesis: an immunohistochemical and morphometrical study. Bull Assoc Anat Nancy, 1996; 80(250)∶17.
9. 贾兰玲，李振，胡萍等. 血型抗原单克隆抗体对乳腺癌新生血管的检测及意义. 中国医科大学学报， 1995； 24(1)∶99.
10. Weidner N, Semple SP, Welch WR, et al. Tumor angiogenesis and metastasiscorrelation in invasive breast carcinoma. N Engl J Med, 1991; 324(1)∶1.
11. Folkman J, Cole P, Zimmerman S. Tumor behavior in isolated perfused organs: in vitro growth and metastasis of biopsy material in rabbit thyroid and canine intestinal segment. Ann Surg, 1966; 164(3)∶491.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

ANALYSIS OF TUMOR ANGIOGENESIS IN BREAST CARCINOMA AND BENIGN BREAST DISEASE

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