To investigate the significance of epidermal growth factor receptor (EGFR) in thyroid carcinoma, the expression of EGFR in 81 samples of thyroid carcinoma were determined by immunohistochemical SP method and comparison among thyroid carcinoma, thyroid adenomas and normal thyroid tissue adjacent to the cancer were made. The results showed: EGFR expression was positive in 45 cases (55.6%) of thyroid carcinoma with no positive expression either in thyroid adenomas or normal thyroid tissue adjacent to the cancer (Ｐ＜0.01). There were no statistical differences between EGFR positive rate and thyroid carcinomatous pathological type, clinical stage, depth of invasion, lymph node metastasis or patients′ postoperative survival time (Ｐ＞0.05). This data suggests that expression of EGFR in thyroid carcinoma is associated with its autonomous growth and malignant phenotype, but it is probably not a useful index for assessing the biological behavious and prognosis of thyroid carcinoma.
Citation：
Chen Yanchang,Chen Daliang,Yin Fengshi.. EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTOR IN HUMAN THYROID CARCINOMAS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(5): 290-291. doi:
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- 1. Iihara K, Shiozaki H, Tahara H, et al. Prognostic significance of transforming growth factorα in human esophageal carcinomas. Cancer, 1993; 71(10)∶2902.
- 2. 王虹， 陈雷， 林丽明等. 免疫组化检测转化生长因子TGFα和p53基因在非小细胞肺癌中的表达. 中华肿瘤杂志， 1996； 18(2)∶84.
- 3. 孙学军， 张培莲. 表皮生长因子受体和增殖细胞核抗原在胃癌中表达的临床意义. 癌症， 1999； 18(1)∶73.
- 4. Haugen DRF, Akslen LA, Varhaug JE, et al. Demonstration of a TGFαEGFreceptor autocrine loop and cmyc protein overexpression in papillary thyroid carcinomas. Int J Cancer, 1993; 55(1)∶37.
- 5. 范文红， 陆应麟， 唐佩弦. 表皮生长因子受体在肿瘤发生和转移中的作用. 国外医学肿瘤学分册， 1997； 24(1)∶9.
- 6. 崔秀娟， 洪生明， 王玲. 表皮生长因子受体在人甲状腺癌的免疫定位. 中华内分泌代谢杂志， 1996； 12(3)∶154.
- 7. Lemoine NR, Wyllie FS, Liliehaug JR, et al. Absence of abnormalities of the Cerb B and Cerb B2 oncogenes in human thyroid neoplasia. Europ J Cancer, 1990; 26(5)∶777.
- 8. Cheifetz RE, Davis NL, Robinson BW, et al. Differentiation of thyroid neoplasmas by evaluating epithelial membrane antigen, Leu7 antigen, epidermal growth factor receptor and DNA content. Am J Surg, 1994; 167(5)∶531.
