This study based on two serial animal experiments: ①caerulein-induced edematous pancreatitis with gut motility inhibited by administration of lopemin (an opium antidiarrheal agent) and ②deoxycholate intraductal-injection induced pancreatitis with gut motility improved by administration of rhubarb solution. The results of these experiments indicated that inhibition of gut motility will increase the incidence of bacterial translocation and endotoxemia during acute pancreatitis; and acceleration of gut motility will significantly decrease the incidence of bacterial translocation and endotoxemia during severe type of acute pancreatitis. The authors conclude that promotion of gut motility may protect the inflammatory pancreas from infection and prevent the multiple organ failure during acute pancreatitis, and eventualy improve the prognosis of pancreatitis.
Citation：
Chen Xiaoli,Feng Kaixiang.. SIGNIFICANCE OF CHANGE OF GUT MOTILITY DURING ACUTE PANCREATITIS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(6): 325-327. doi:
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| 1. |
Renner IG, Savage WT, Panbtoja TL, et al. Death due to acute pancreatitis: a retrospective analysis of 405 autopsy cases. Dig Dis, 1985; 30(3)∶1005.
|
| 2. |
Rabeneck L, Feinstein A, Horwitz RL, et al. A new clinical prognostic staging system for acute pancreatitis. Am J Med, 1993; 95(1)∶61.
|
| 3. |
Schmidt J, Warshaw AL. A better model of acute pancreatitis for evaluating therapy. Ann Surg, 1992; 215∶44.
|
| 4. |
Sharahan F. The intestinal immune system. In: Johnson LR ed. Physiology of gastrointestinal tract. 3th ed. New York: Raven Press Ltd, 1994; 1(2)∶643.
|
| 5. |
Scott LD. Influence of influence of interdigestive myoelectric complex on enteric flora in rat. Gastroenterology, 1982; 82(3)∶737.
|
| 6. |
Runkel NSF, Moody FG, Smith GS, et al. The role of the gut in development of sepsis in acute pancreatitis. J Surg Res, 1991; 51(1)∶18.
|
| 7. |
Shikata J, Shida T, Amino K. Experimental study on hemodynamic of small intestine following increased intraluminal pressure. Surg Gynecol Obsttet, 1983; 156(1)∶155.
|
- 1. Renner IG, Savage WT, Panbtoja TL, et al. Death due to acute pancreatitis: a retrospective analysis of 405 autopsy cases. Dig Dis, 1985; 30(3)∶1005.
- 2. Rabeneck L, Feinstein A, Horwitz RL, et al. A new clinical prognostic staging system for acute pancreatitis. Am J Med, 1993; 95(1)∶61.
- 3. Schmidt J, Warshaw AL. A better model of acute pancreatitis for evaluating therapy. Ann Surg, 1992; 215∶44.
- 4. Sharahan F. The intestinal immune system. In: Johnson LR ed. Physiology of gastrointestinal tract. 3th ed. New York: Raven Press Ltd, 1994; 1(2)∶643.
- 5. Scott LD. Influence of influence of interdigestive myoelectric complex on enteric flora in rat. Gastroenterology, 1982; 82(3)∶737.
- 6. Runkel NSF, Moody FG, Smith GS, et al. The role of the gut in development of sepsis in acute pancreatitis. J Surg Res, 1991; 51(1)∶18.
- 7. Shikata J, Shida T, Amino K. Experimental study on hemodynamic of small intestine following increased intraluminal pressure. Surg Gynecol Obsttet, 1983; 156(1)∶155.
