• Department of General Surgery, The First Affiliated Hospital,Inner Mongolia College, Huhhot 010050;
Export PDF Favorites Scan Get Citation

To study the role of endotoxin in acute hemorrhagic necrotizing pancreatitis (AHNP), the change of endotoxin were studied in rats AHNP models by injection of 5% sodium taurocholate 1 ml/kg into pancreatic duct, and the effects of recombinant interleukin-2 (IL-2) in the treatment of AHNP were observed in this experiment. The results indicated that endotoxin involved the aggravation of AHNP and was associated with the increase of serum phospholipas-2 (PLA2), and these mediators were positively correlated with severe degrees of pancreatic damage. The results also suggeste that IL-2 might inhibit the overexpression of endotoxin and PLA2 and mitigate the pancreatic injury and decrease the 72h-mortality rate of AHNP from 66.7% to 26.7% (P<0.01). Endotoxin might play a major role in the pathogenesis of AHNP and IL-2 might have a potential role in the treatment of AHNP.

Citation: Wang Wanxiang,Zhao Haiping,Shou Naiyan,et al.. THE ROLE OF ENDOTOXIN ON EXPERIMENTAL ACUTE HEMORRHAGIC NECROTIC PANCREATITIS AND THERAPEUTIC EFFECT OF INTERLEUKIN-2. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(6): 339-341. doi: Copy