The purpose of this study was to determine the contribution of endotoxin (ET) in ocurrence and progression of acute pancreatitis (AP). The results indicated that correlation of ET changes with multiple organ damage in AP. The degree of ET elevation correlated well with the severty of AP. The level of plasma ET of severe AP patients was much higher than that of mild AP patients (Ｐ＜0.05). The chance of multiple organ damage got greater while the plasma ET level got higher. Moreover, the severety change of severe AP correlated with the change of plasma ET level. In other words, the ET level was reduced while the disease was recovering, elevated while it was becoming worse and maintained high level in dead cases. We think that plasma ET level can be used as a reference for differenciating mild AP with severe AP and a predictor for the prognosis of AP.
Citation：
Hu Weiming,Zhang Zhaoda,Tian Bole.. CHANGES AND CLINICAL SIGNIFICANCE OF PLASMA ENDOTOXIN LEVEL IN ACUTE SEVERE PANCREATITIS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(6): 350-351. doi:
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- 1. Ranson JHC, Balthayar E, Caccarale R, et al. Computed tomography and predicton of pancreatic abscess in acute pancreatitis. Ann Surg, 1985; 201(5)∶656.
- 2. 胡伟明， 张肇达. 急性坏死性胰腺炎血浆内毒素水平与多器官损害的实验研究. 普外基础与临床杂志， 1996； 3(增刊)∶104.
- 3. Kazantser GB, Hecht DW, Rao R, et al. Plasmid labeling comfirms bacterial translocation in pancreatitis. Am J Surg, 1994; 167(1)∶201.
- 4. Exley AR, Leese T, Holliday， et al. Endotoxaemia and serum tumor necrosis factor as prognostic markers in severe acute pancreatitis. Gut, 1992; 33(8)∶1126.
- 5. 黄宗文， 蒋俊明， 杨学海等. 急性胰腺炎血浆内毒素检测及其临床意义. 华西医学， 1992； 7(4)∶414.
- 6. Windsor JA, Fearon KC, Ross JA, et al. Role of serum endotoxin core antibody levels in predicting the development of multiple organ failure in acute pancreatitis. Br J Surg, 1993; 80(8)∶1042.
- 7. Manthous CA, Hall JB, Samsel RW. Endotoxin in human disease part 1: biochemistry assay, and possible role in diverse disease states. Chest, 1993; 104(5)∶1572.
