THE ROLE OF INTRACELLULAR CALCIUM IN THE CONTRACTIONS OF INTERNAL ANAL SPHINCTER_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Zhongshan Hospital, Shanghai Medical University, Shanghai 200032;

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Intracellular calcium; Internal anal sphincter

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From this experiment we found that acetylcholine (Ach) was the agonist of the colonic smooth muscles, and noradrenaline (NA) the internal anal sphincter(IAS). The contractions of colonic smooth muscles were significantly inhibited under the calcium-free solution (Ｐ＜0.01), but the IAS was not affected. Ryanodine, which can exhaust the intracellular calcium, remarkably depressed the contractions of IAS (Ｐ＜0.01),but had no effect on the colonic smooth muscles. It can be concluded that the contractions of colonic smooth muscles are mainly related to the influx of extracellular calcium; the release of intracellular calcium plays an important role in the contractions of IAS.

Citation： Niu Weixin,Qin Xinyu,Lu Yingqin,et al.. THE ROLE OF INTRACELLULAR CALCIUM IN THE CONTRACTIONS OF INTERNAL ANAL SPHINCTER. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(1): 7-8. doi: Copy

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1. O’Kelly TJ, Brading A, Mortensent NJM. In vitro response of the human anal canal longitudinal muscle layer to cholinergic and adrenergic stimulation: evidence of sphincter specialization. Br J Surg, 1993; 80(10)∶1337.
2. Bitar KN, Bridford P, Putney JW, et al. Cytosolic calcium during contraction of isolated mammalian gastric muscle cell. Science, 1986; 232∶1143.
3. Jender DJ, Fairhurst AS. The pharmacology of ryanodine. Pharmacol Rev, 1969; 21(1)∶1.
4. Iino M, Kobayashi T, Endo M. Use of ryanodine for functional removal of the calcium store in smooth muscle cells of the guineapig. Biochem Biophys Res Comm, 1988; 152(1)∶417.
5. Burgoyne RD, Check TR. Locating intracellular calcium stores. Science, 1991; 16(9)∶319.
6. Kwan CY, Zhang ZD, Bourreau JP. Intracellular calcium release channel in smooth muscle as studied with ryanodine. Acta Pharmacol Sin,1992; 13(1)∶76.
7. Frenker B, Euler CV. Influence of pudendal block on the function of the anal sphincters. Gut,1975; 16(6)∶482.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

THE ROLE OF INTRACELLULAR CALCIUM IN THE CONTRACTIONS OF INTERNAL ANAL SPHINCTER

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