Gastrin(G) concentration in fasting blood, cancer tissues and its adjacent mucosas sampled from fourty-three patients with large intestine carcinoma (LIC) were measured. The results showed fasting G levels in patients with LIC were significantly higher than those in the normal surum controls (Ｐ＜0.05),and dropped to normal value after resection of the cancers. Surum G levels were correlated with cell differentiations of the cancer.The cancer tissues and its adjacent mucosas contained higher levels of G than the normal mucosas (Ｐ＜0.05). The results provided a laboratory evidence that the growth of LIC in vivo were regulated by G and G level might be an indicative parameter for selection of patients with LIC to be treated with hormone therapy and the study of biological character of LIC.
Citation：
Li Jiaqi,He Shuangwu,Li Yiren,et al.. CLINICAL STUDY OF GASTRIN IN SURUM AND TISSUES OF LARGE INTESTINE CARCINOMA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(1): 16-18. doi:
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- 1. Singh P, Walker JP, Townsend CM, et al.Role of gastrin and gastrin receptors on the growth of a transplantable mouse colon carcinoma (MC26) in BALB/C mice. Cancer Res, 1986; 46∶1612.
- 2. Watson SA, Durrant LG, Croshic JD,et al. The in vitro growth response of primary human colorectal and gastric cancer cells to gastrin. Int J Cancer, 1989； 43∶692.
- 3. Smith JP, Wood JG, Soloman TE. Elevated gastrin levels in patients with colon cancer or adenomatous polyps. Digestive Dis Science, 1989; 34(2)∶171.
- 4. Wang K, Beardshall K, Waters CM,et al. Postprandial hypergastrinameic in patients with colorectal cancer. Gut, 1991; 32∶1352.
- 5. 蔡文琴，王伯云.实用免疫细胞化学室. 成都：四川科学技术出版社，1988∶214.
- 6. Nemeth J,Taylor B, Pauwels S, et al.Indentification of progastrin derived peptide in colorectal carcinoma extracts. Gut, 1993; 34(1)∶90.
- 7. Waston SA, Durrant LG, Wencyk PM, et al.Intracellular gastrin in human gastrointestinal tumor cells. National Cancer Institute, 1991; 83(12)∶866.
- 8. Hoosein NM, Diener PA, Curry RC, et al. Evidence for autocrin growth stimulation of cultured colon tumor cells by a gastrin cholecystokininlike peptide. Experimental Cell Research, 1990; 186∶15.
- 9. 张群星，曾民德，施尧等. 胃癌组织及癌旁粘膜的胰高血糖素、胰岛素和胃泌素含量的测定. 中华消化杂志， 1991； 11(3)∶144.
- 10. Imdall A， Eggstein ST, Crance C,et al. Growth of colorectal carcinoma cell:regulation in vitro by gastrin, pentagastrin and the gastrinreceptor antagonist proglumid. J Cancer Res Clinocol, 1989; 115∶388.
- 11. Beauchamp RD, Townsand CM, Singh P,et al.Proglumid,a gastrin receptor antagonist, inhibit growth of colon cancer and enhances survival in mice. Ann Surg, 1985; 302(3)∶303.
