PROTECTIVE EFFECT OF SODIUM DEOXYCHOLATE AND LACTULOSE ON OBSTRUCTIVE JAUNDICED INTESTINAL MUCOSA_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

Wang Xiyan ¹ , Ping Xiaojia. ²

Department of General Surgery, First Affiliated Hospital, Xinjiang medical College, Wulumuqi 830000;

Corresponding author：

Keywords：

Obstructive jaundice; Intestinal mucosa; Sodium deoxycholate; Lactulose

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This experimental study was aimed at observing the influence of bile salt and lactulose on intestinal mucosa of obstructive jaundiced rat. Twenty adult Wistar rate were divided into four groups (five rats for each group): sham operation, common bile duct ligation (CBDL), CBDL plus sodium deoxycholate feeding and CBDL plus lactulose feeding. The results showed that the intestinal mucosa of rats with obstructive jaundice took on marked edema, markedly decreased activities of adenosine triphosphatase, alkaline phosphatase and succinic dehydrogenase and intensified acid phosphatase activity. However, the intestinal mucosa of the rats, treated with bile salt or lactulose as compared with that of the obstructive jaundiced rats showed both pathological and histochemical improvement.

Citation： Wang Xiyan,Ping Xiaojia.. PROTECTIVE EFFECT OF SODIUM DEOXYCHOLATE AND LACTULOSE ON OBSTRUCTIVE JAUNDICED INTESTINAL MUCOSA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(2): 80-81. doi: Copy

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1. 王喜艳. 梗阻性黄疸引起肾脏损害的病理机制. 石河子医学院学报， 1992； 14(4)∶242.
2. 陈啸梅，周文郁，彭俊云等. 组织化学手册. 北京：人民卫生出版社， 1982∶136～224.
3. Deitch EA, Sittig KM, Ma L, et al. Obstuctive jaundice promotes bacterial translocation from the gut. Am J Surg, 1990; 159(1)∶79.
4. Slocum MM, Sittig KM, Specian RD, et al. Absence of intestinal bile promotes bacterial translocation. Am Surg, 1992; 58(5)∶305.
5. Pain JA, Cahill CJ, Bailey ME, et al. Prevention of postoperative renal dysfunction in patients with obstructive jaundice： A multicentre study of bile salts and lactulose. Br J Surg, 1991; 78(4)∶467.
6. Pain JA, Bailey ME, Cahill CJ, et al. Experimental and clinical study of lactulose in obstructive jaundice. Br J Surg, 1986; 73(10)∶75.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

PROTECTIVE EFFECT OF SODIUM DEOXYCHOLATE AND LACTULOSE ON OBSTRUCTIVE JAUNDICED INTESTINAL MUCOSA

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