CHANGES OF SPLANCHNIC VASCULAR ANGIOTENSIN Ⅱ RECEPTORS IN RATS WITH PORTAL HYPERTENSION_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

Li Jikun ¹ , Dai Zhiben ² , Cui Wuren. ³

Department of Surgery, Shanghai First People’s Hospital,Shanghai 200080;

Corresponding author：

Keywords：

Portal hypertension; AngiotensionⅡ receptor; Radioligand assay

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To investigate the mechanisms of splanchnic hyperdynamics in portal hypertension (PHT), angiotensin Ⅱ(A-Ⅱ) receptor maximal binding capacity (Bmax) and dissociation constants (Kd) of splanchnic blood vessels in rats with prehepatic PHT were studied by radioligand binding analysis. The results showed that the A-Ⅱ receptor Bmax in the superior mesenteric artery and portal vein of PHT animals (206.9±39.3 fmol/mg protein and 31.5±9.2 fmol/mg protein respectively) was all significantly lower than that of the controls (297.2±44.7 fmol/mg protein and 53.4±12.1 fmol/mg protein respectively, Ｐ＜0.01). The A-Ⅱ receptor Kd in the superior mesenteric artery was markedly increased in PHT animals (1.03±0.11 nmol/L) compared with that in controls (0.88±0.08 nmol/L, Ｐ＜0.05). In the portal vein, the A-Ⅱ receptor Kd in PHT animals was slightly higher than in controls, but no significant difference was observed between the two groups. These results suggest that the vascular hyporesponsiveness to A-Ⅱ in PHT is caused partially by a reduction in number and a decrease in affinity of vascular A-Ⅱ receptors, and these changes may possibly lead to the formation of hyperdynamic circulation.

Citation： Li Jikun,Dai Zhiben,Cui Wuren.. CHANGES OF SPLANCHNIC VASCULAR ANGIOTENSIN Ⅱ RECEPTORS IN RATS WITH PORTAL HYPERTENSION. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(3): 140-142. doi: Copy

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5.	Wu YP, Li SS, Campbell KA, et al. Modulation of splanchnic vascular sensitivity to angiotensin Ⅱ. Surgery, 1991; 110(2)∶162.
6.	Malmqvist U. Effects of longterm portal hypertension on structure, active force and contant of contratile and structural proteins in smooth muscle of the rat portal vein. Acta Physiol Scand, 1994; 150(1)∶171.
7.	Aquilera A, Catt K. Regulation of vascular angiotensinⅡ receptors in the rat during altered sodium intake. Circ Res, 1981; 49(4)∶751.
8.	Cahill PA, Redmond EM, Foster C, et al. Nitric oxide regulates angiotensin Ⅱ receptors in vascular smooth muscle cells. Eur J Pharmacol, 1995; 288(2)∶219.
9.	Corriu C, Andre P, Schott C, et al. Ang Ⅱ receptor expression and function during phenotypic modulation of rat aortic smooth muscle cells. Am J Physiol, 1994; 266(3)∶H631.

1. Sitzmann JV, Li SS, Wu YP, et al. Decreased mesenteric vascular response to angiotensin Ⅱ in portal hypertension. J Surg Res, 1990; 48(4)∶341.
2. Vorobioff J, Bredfeldt JE, Groszmann RJ. Hyperdynamic circulation in portalhypertensive rat model: a primary factor for maintenance of chronic portal hypertension. Am J Physiol, 1983; 244(7)∶G52.
3. Castro A, Jimenez W, Claria J, et al. Impaired responsiveness to angiotensin Ⅱ in experimental cirrhosis: role of nitric oxide. Hepatology, 1993; 18(8)∶367.
4. Meng HC, Lin HC, Tsai YT, et al. Relationship between the severity of cirrhosis and hemodynamic values in patients with cirrhosis. J Gastroenterol Hepatol, 1994; 9(2)∶148.
5. Wu YP, Li SS, Campbell KA, et al. Modulation of splanchnic vascular sensitivity to angiotensin Ⅱ. Surgery, 1991; 110(2)∶162.
6. Malmqvist U. Effects of longterm portal hypertension on structure, active force and contant of contratile and structural proteins in smooth muscle of the rat portal vein. Acta Physiol Scand, 1994; 150(1)∶171.
7. Aquilera A, Catt K. Regulation of vascular angiotensinⅡ receptors in the rat during altered sodium intake. Circ Res, 1981; 49(4)∶751.
8. Cahill PA, Redmond EM, Foster C, et al. Nitric oxide regulates angiotensin Ⅱ receptors in vascular smooth muscle cells. Eur J Pharmacol, 1995; 288(2)∶219.
9. Corriu C, Andre P, Schott C, et al. Ang Ⅱ receptor expression and function during phenotypic modulation of rat aortic smooth muscle cells. Am J Physiol, 1994; 266(3)∶H631.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

CHANGES OF SPLANCHNIC VASCULAR ANGIOTENSIN Ⅱ RECEPTORS IN RATS WITH PORTAL HYPERTENSION

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