To evaluate the biological tolerance of the human liver to prolonged warm ischemia, 20 patients who underwent liver resections with hepatic inflow occlusion are reported. Biopsy of liver were performed during and after consecutive periods of hepatic ischemia, and speciments were observed under light and electron microscope. The results showed that hepatic vascular occlusion for ＜30 min, resulted in atotissular temporary but reversible pathologic and ultrastructural changes in liver, even patients with liver cirrhosis had better recovery from the operation when the hepatic ischemia was lengthen up to 40 min.
Citation：
Tu Kequan,Liang Chuanfang,Lun Zengjun,et al.. THE CLINICAL STUDIES OF PATHOLOGIC AND ULTRASTRUCTURAL ALTERATIONS OF LIVER AFTER HEPATIC VASCULAR OCCLUSION UNDER NORMOTHERMIA IN HUMAN. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(4): 226-227. doi:
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Nagusue N. Tolerance of the cirrhotic liver to normothemic a clinical study of 15 patients. Am J Surg, 1984; 147∶722.
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Delva E. Vascular occlusion for liver resection. Ann Surg, 1989; 209∶211.
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韩明，吕新生.常温下长时间阻断肝脏血供在非肝硬变肝切除手术中的应用.中华外科杂志，1992； 30(6)∶329.
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袁玫，彭志明，张桂香.实验性犬肝急性缺血后组织形态及超微结构的变化.中华病理学杂志， 1984； 13(4)∶291.
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- 1. 吴孟超.肝脏疾病.见：吴阶平，裘法祖主编.黄家驷外科学.第5版.北京：人民卫生出版社，1992∶1335～1336.
- 2. 吴在德.肝癌.见：裘法祖，孟承伟主编.外科学.第2版.北京：人民卫生出版社，1984∶504.
- 3. 夏穗生.常温肝切除人肝血流阻断法的探讨.腹部外科，1989； 2(4)∶159.
- 4. 彭淑牖.肝脏解剖分段与肝段切除术现状.见：高根五，夏亮芳主编.腹部外科学进展.第1版.成都：四川科技出版社，1992∶190～201.
- 5. Huguet C, Nordlinger B, Block P, et al.Normothermic hepatic vascular exclusion for extensive hepatectomy. S G O, 1978; 147∶689.
- 6. Dulva E. hemodynamic and biochemical monitoring during major liver resection with use of hepatic vascular exclusion. Surgery, 1984; 95∶309.
- 7. Huguet C, Nordlinger B, Bloch P, et al.Tolerance of the human liver to prolonged normothermic ischemia. Arch Surg, 1978; 113∶1448.
- 8. Kahn D, Hickman R, Dent DM, et al.For how long can the liver tolerate ischemia? Eur Surg Res. 1986; 18∶277.
- 9. 陈孝平，吴在德，裘法祖.家兔常温下阻断肝门最大耐受时限的临床研究.中华肿瘤杂志，1984； 22(2)∶153.
- 10. 陈孝平，吴在德，叶启发等.常温下阻断入肝血流行肝切除81例临床观察.中化肿瘤杂志，1991； 29(2)∶84.
- 11. 陈孝平，吴在德.肝切除术中常温阻断入肝血流时间的探讨.中华外科杂志， 1989； 27(9)∶523.
- 12. Nagusue N. Tolerance of the cirrhotic liver to normothemic a clinical study of 15 patients. Am J Surg, 1984; 147∶722.
- 13. Delva E. Vascular occlusion for liver resection. Ann Surg, 1989; 209∶211.
- 14. 韩明，吕新生.常温下长时间阻断肝脏血供在非肝硬变肝切除手术中的应用.中华外科杂志，1992； 30(6)∶329.
- 15. 袁玫，彭志明，张桂香.实验性犬肝急性缺血后组织形态及超微结构的变化.中华病理学杂志， 1984； 13(4)∶291.
