The expression of C-erb B-2 oncogene protein in the tissues of normal breast, atypical cystic hyperplasia of breast and breast carcinoma were determined in order to analyse the significance of the changes of C-erb B-2 oncogene in the course from atypical hyperplasia to carcinoma of breast. Results: there were no expression of C-erb B-2 protein in the tissues of normal breast and cystic hyperplasia of breast with epithelia proliferation grade Ⅰ. The positive rates of the expressions of C-erb B-2 protein in the tissues of atypical hyperplasia grades Ⅱ, Ⅲ and carcinoma of breast were 20.0%, 40.0% and 54.2% respectively. The results indicated that the abnormal changes of C-erb B-2 nocogene might occured in the carcinomatous transformation phase along with the changes from normal breast epithelial cell through atypical hyperplasia to breast cancer, those changes could be the result or promotion factor of abnormal proliferation of atypical hyperplasia of breast and was one of the markers of malignant transformation of epithelia of breast.
Citation：
Jiang Jun,Chen Yisheng,Ma Hongmin,et al.. THE RELATIONSHIP BETWEEN THE EXPRESION OF C-erb B-2 ONCOGENE PROTEIN IN ATYPICAL HYPERPLASIA OF BREAST AND BREAST CARCINOGENESIS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(5): 257-259. doi:
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- 1. Page DL. Cancer risk assessment in benign breast biopsies. Human Pathol, 1986; 17(8)∶871.
- 2. 李树玲.乳腺癌.见：中华人民共和国医政司编.中国常见恶性肿瘤诊治规范(第八分册).北京：北京医科大学中国协和医科大学出版社，1991∶25～58.
- 3. Gusterson BA, Gullick WJ, Venter DJ, et al. Immunohistochemical localization of Cerb B2 in human breast carcinomas. Mol Cell Probes, 1988; 2(1)∶383.
- 4. Slamon DJ, Clark GM, Wong SG, et al. Huamn breast cancer:correlation of relapse and survival with amplification of the HER2/neu oncogen. Science, 1987; 235(4785)∶177.
- 5. Bacus SS, Ruby SG, Weinberg DS, et al. HER2/neu oncoprotein expression and proliferation in breast cancer. Am J Pathol, 1990; 137(1)∶103.
- 6. 叶锋，黄冰，黄书伟.乳腺肿瘤中Cerb B2癌基因产物的表达及意义.中华病理学杂志，1993； 22(2)∶104.
- 7. Hamna W, Kahn HJ, Andrulis I, et al. Distribution and patterns of staining of neu oncogene product in benign and malignant breast diseases. Mod Pathol, 1990; 3(4)∶455.
- 8. Lodato RF, Maguire HC, Greene MI, et al. Immunohistochemical evaluation of Cerb B2 oncogene expression in ductal carcinoma in situ and atypical ductal hyperplasia of breast. Mod Pathol, 1990; 3(4)∶449.
- 9. Ramachandra S, Machin L, Ashley S, et al. Immunohistochemical distribution of Cerb B2 in situ breast carcinoma: a detailed morphological analysis. J Pathol, 1990; 161(1)∶7.
