STUDY ON GASTRIC MUCOSAL INJURY INDUCED BY SHOCKREPERFUSION IN PORTAL HYPERTENSION RATS WITH CIRRHOSIS_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

Xu Zekuan , Zhang Baokang.

The First Affiliated Hospital of Nanjing Medical Univeristy, Nanjing 210029;

Corresponding author：

Keywords：

Oxygen free radicals; Superoxide dismutase; Portal hepertension; Shock-reperfusion

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Electron spin resonance (ESR) spectroscopy and spin trapping agent PBN were applied to measure directly the changes of oxygen free redicals (OFR) in gastric mucosa of rats with portal hypertension (PHT) injured by shockreperfusion, and treated with superoxide dismutase (SOD), radix salviae miltiorrhizae (RSM), with concomitant monitoring activity of SOD and pathology of gastric mucosa. Results showed that the amount of OFR increased markedly in gastric mucosa of PHT rats during the shock-reperfusion. The pathological changes were in accordance with alteration of the amount of OFR and the activity of SOD. Gastric mucosa in PHT was more susceptible to shock-reperfusion insult than normal controls. The anti-oxidant SOD, RSM used at early stage exerted mild gastric mucosal insult through different mechanisms.

Citation： Xu Zekuan,Zhang Baokang.. STUDY ON GASTRIC MUCOSAL INJURY INDUCED BY SHOCKREPERFUSION IN PORTAL HYPERTENSION RATS WITH CIRRHOSIS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(5): 267-269. doi: Copy

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2. Kirk AP, Dooley JS, Hunt RH. Peptic ulceration in patients with chronic liver disease. Dig Dis Sci, 1980; 25(10)∶756.
3. Lai EK, Crossley C, Sridhar R, et al. In vivo spin trapping of free redicals generated in brain, spleen, and liver during radiation of mice. Arch Biochem Biophy, 1986; 244(1)∶156.
4. Kuppusamy P, Zweier JL. Characterization of free radical generation by xanthine oxidase. J Biolchem, 1989; 264(17)∶9880.
5. Zweier JL, Flaherty JT, Weisfeldt ML. Direct measurement of free radical generation following reperfusion ischemia myocardium. Med Sci, 1987; 84(5)∶1404.
6. Sarfeh IJ, Tarnawski A. Increased susceptibility of the portal hypertensive gastric mucosa to damage. J Clin Gastroenterol, 1991; 13(Suppl 1)∶S18.
7. Perry MA, Wadhwa S, Parks DA, et al. Role of oxygen radicals in ischemiainduced lesions in the cat stomach. Am J Physiol, 1988; 254(3)∶366.
8. 黄梅芳，邓长生，易季云等.丹参对实验性急性乙醇胃粘膜损伤的保护作用及其机理的研究.中华消化杂志，1996； 16(2)∶82.
9. 岳平.丹参酮ⅡA碳酸钠与钙反常心肌保护作用.病理生理学报，1985； 1(5)∶165.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

STUDY ON GASTRIC MUCOSAL INJURY INDUCED BY SHOCKREPERFUSION IN PORTAL HYPERTENSION RATS WITH CIRRHOSIS

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