InordertounderstandtherelationshipofP62CmycproteinexpressiontoERandPRinbreastcanceranditsclinicalsignificance,weexaminedexpressionofP62Cmycproteinin107breastcarcinomasbyusingimmunohistochemicaltechniques(LSAB).TheresultsshowedthatthepositiverateofP62Cmycproteinexpressionwas63.55%(68/107).TheoverexpressionofP62Cmycproteinrelatednegativelywithsurvival.94.00%ofthecaseswithoverexpressionofP62Cmycproteinsurvived≤5years,65.00%survived gt;5years lt;10yearsand21.62%survived≥10years.ThereweresignificantassociationsofP62Cmycproteinexpressionwithadvancedclinicalstage,highhistologicalgrade,andpositiveaxillarynodestatusinbreastcancer,butnorelationshipbetweenhormonereceptorsandP62Cmyc.AllofthesefindingssuggestthatoverexpressionofP62Cmycproteinmightbeanimportantprognosticfactor,andthedetectionofP62Cmycproteinmightbearrangedasaregularpathologicalexaminationinthecasesofbreastcancer.
Citation：
YangJinqiao,ZhouLeilei,LiangCuiping,etal.. RELATIONSHIPOFP62CmycPROTEINEXPRESSIONTOESTROGENPROGESTERONERECEPTORSINBREASTCANCERANDITSCLINICALSIGNIFICANCE. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(5): 270-271. doi:
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Copyright © the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
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- 1. 姚先莹,孟宪钦,陈佩珍等.乳腺癌与性类固醇激素受体水平的关系及其意义.四川医学,1985;6(6)∶348.
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- 4. RamsayG,EvanGI,BishopJM.TheproteinencodedbythehumanprotooncogeneCmyc.ProgNatlAcadSciUSA,1984;81(24)∶7742.
- 5. EvanG,HancockDC.StudiesontheinteractionofthehumanCmycproteinwithcellnuclei:P62Cmycasamemberofadiscretesubsetofnuclearproteins.Cell,1985;43(1)∶253.
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