CHANGES OF SERUM NITRIC OXIDE LEVELS AND THERAPEUTIC EFFECTS OF SODIUM NITROPRUSSIDE IN ACUTE HEMORRHAGIC NECROTIZING PANCREATITIS IN RATS_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of General Surgery, The Jiamusi Medical College, Jiamusi 154002;

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Keywords：

Acute hemorrhagic necrotizing pancreatitis; Nitric Oxide; Sodium nitroprusside

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To investigate changes of serum nitric oxide (NO) levels and therapeutic effects of sodium nitroprusside (SNP) in acute hemorrhagic necrotizing pancreatitis (AHNP) in rats, one hundred and twenty Wistar rats were divided into three groups randomly (forty in each group) animal models of AHNP group were produced by retrograde injection of 5% sodium taurocholate into pancreatobiliary duct.In the treatment group SNP (0.05mg/100g) was injected intraperitoneally after AHNP models established and then repeated three hours later. In the control group only retrograde injection of normal saline (0.5ml) into pancreatobiliary duct was performed. The results showed: compared with the treatment group, serum NO and SOD levels were significantly lower in AHNP group (Ｐ＜0.05); serum amylase levels and pancreatic indexes were markedly higher in AHNP (Ｐ＜0.01 and Ｐ＜0.05 respectively);the mortality in 24 hours was significantly higher and survival time was significantly shorter in AHNP group (Ｐ＜0.01).Pathologic changes of pancreas were significantly severe in AHNP group. From the above results we can draw the conclusion that NO plays an important role in the pathogenesis of AHNP and SNP has therapeutic effects on AHNP in rats.

Citation： Hu Dapeng,Li Zhiqiang,Chu Yanhui,et al.. CHANGES OF SERUM NITRIC OXIDE LEVELS AND THERAPEUTIC EFFECTS OF SODIUM NITROPRUSSIDE IN ACUTE HEMORRHAGIC NECROTIZING PANCREATITIS IN RATS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(6): 340-342. doi: Copy

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1. Konturek ST, Bliski J, Konturek PK, et al. Role of endogenous nitric oxide in the control of canine pancreatic secretion and blood flow. Gastroenterology, 1993; 104(4)∶896.
2. Xiaohong LIV. Protective effect of nitric oxide on development of acute pancreatitis in rats. Digestive Diseases and Sciences, 1995; 40(10)∶2162.
3. Aho HJ. Experimental pancreatitis in the rat: sodium taurocholate induced acute hemorrhagic pancreatitis. Scand J Gastroenterol, 1980; 15(3)∶411.
4. Furchgott RF, Zanaduzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetycholine. Nature, 1980; 288(4)∶373.
5. 张延龄.一氧化氮与外科.国外医学.外科学分册，1996；23(3)∶150.
6. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev, 1991; 43(1)∶109.
7. Xavier M. Nitric oxide modulates pancreatic basel secretion and response to cerulein in the rat: effects in acute pancreatitis. Gastroenterology, 1995; 108(4)∶1855.
8. Arndt H, Russell JB, Kurose I, et al. Mediators of leukocyte adhesion in rat mesenteric venules elicited by inhibition of nitric oxide synthesis. Gastroenterology, 1993; 105(3)∶675.
9. Ialenti A, Ianaro A, Moncada S, et al. Modulation of acute in flammation by endogenous nitric oxide. Eur J Pharmacol, 1992; 211(2)∶177.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

CHANGES OF SERUM NITRIC OXIDE LEVELS AND THERAPEUTIC EFFECTS OF SODIUM NITROPRUSSIDE IN ACUTE HEMORRHAGIC NECROTIZING PANCREATITIS IN RATS

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