EFFECTS OF HYPERTHERMIA COMBINED WITH MITOMYCIN,5-FLUOROURACIL IN VITRO ON HUMAN GASTRIC CARCINOMA CELL_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

Wang Yaxu , Wang Daike , Liu Baokua.

Department of General Surgery,Research Institude of Surgery,Daping Hospital,The Third Medical University,Chongqing 630042;

Corresponding author：

Keywords：

Hyperthermia; 5-Fluorouracil; Mitomycin; Percentage of living cells; Plating efficiency; Survival fraction

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The antitumor activity of hyperthermia combined with mitomycin(MMC),5-fluorouracil(5-Fu)was observed in human gastric carinoma cell line MGC-803.The study was aimed at understanding the percentage of living carcinoma cell,plating efficiency and survival fraction.The results showed that hyperthermia combined
with MMC had a synergistic antitumor activity which was enhanced with temperature increasing,but it was not the same as hyperthermia combined with 5-Fu.In comparison with simple hyperthermia,the antitumor activity of hyperthermia combined with 5-Fu was enhanced at lower temperture.This results raises a basis of clinical practice.

Citation： Wang Yaxu,Wang Daike,Liu Baokua.. EFFECTS OF HYPERTHERMIA COMBINED WITH MITOMYCIN,5-FLUOROURACIL IN VITRO ON HUMAN GASTRIC CARCINOMA CELL. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1997, 4(1): 1-3. doi: Copy

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8.	赵晓光,张凤兰,徐浩梁等. 增强高温对肿瘤效应一些因素的探讨. 中华病理学杂志,1988;17(1) : 69.
9.	Storm FK. Hyperthermia in cancer therapy.G.K Hall Medical Publishers.Boston:Massachusetts,1983 : 142.
10.	南京医学院,南京医学院附一院.临床药物手册.第2版.上海:上海科学技术出版社,1986 : 86.
11.	Beverly AT,Charles DK,Katherine AK,et al. Enhancement by hyperthermia of the in vitro cytotoxity of mitomycin C toward hypoxic tumor cells. Cancer Res,1979;39 : 2245.
12.	Storm FK,William HH,Robert SE,et al. Normal tissue and solid tumor effects of hyperthermia in animal models and clinical trials.Cancer Res,1979;39 : 2245.
13.	杨耀琴,杨虎川,陶惠红等.温热(39~45℃)合并丝裂霉素C对BGC-823人胃癌细胞的抑制效应.上海铁道医学院学报,1990;4(2) : 92.
14.	Yasunori E,Shunji K,Motofumi Y,et al. Hyperthermia enhances the i9nhibition of tumor growth by 1-(2-tetrahydrofuryl)-5-Fluorouracil/Uracil(1:4)in tumorsin mice and humans.Cancer,1992;70 : 1177.
15.	宁守诚,张锡泽.恶性肿瘤加热治疗的进展.中国肿瘤临床,1986;13(4) : 220.

1. Love R.Effent of hyperhtermia on normal and neoplastic cells in vitro.Cancer Res,1970;30 : 1525.
2. Mondovi B. The biochemical mechanism of selective heat sensitivity of cancer cells II . Studies on nucleic acids and protein synthesis. Eur J Cancer,1969;.
3. 松田忠义. 温热化学疗法的现状. 日本医学介绍,1989;10(11) : 496.
4. 王凯华. 人体低分化粘液腺癌细胞系MGC-803的建立及其生物学特性的初步观察. 实验生物学学报, 1983;16(3) : 257.
5. : 137.
6. Stehlin JS. Results of hyperthermic perfusion for melsnoma of the extremities. Surg Gynecol Obster, 1975;140:338.
7. Norbert JR.Shintsu Lu,Solm M. Hyperthermia and human leukocyte functions:DNA,RNA,and total protein systhesis after exposure to <41℃ or >42.5℃ hyperthermia.Cancer Res,1985;45 : 3076.
8. 赵晓光,张凤兰,徐浩梁等. 增强高温对肿瘤效应一些因素的探讨. 中华病理学杂志,1988;17(1) : 69.
9. Storm FK. Hyperthermia in cancer therapy.G.K Hall Medical Publishers.Boston:Massachusetts,1983 : 142.
10. 南京医学院,南京医学院附一院.临床药物手册.第2版.上海:上海科学技术出版社,1986 : 86.
11. Beverly AT,Charles DK,Katherine AK,et al. Enhancement by hyperthermia of the in vitro cytotoxity of mitomycin C toward hypoxic tumor cells. Cancer Res,1979;39 : 2245.
12. Storm FK,William HH,Robert SE,et al. Normal tissue and solid tumor effects of hyperthermia in animal models and clinical trials.Cancer Res,1979;39 : 2245.
13. 杨耀琴,杨虎川,陶惠红等.温热(39~45℃)合并丝裂霉素C对BGC-823人胃癌细胞的抑制效应.上海铁道医学院学报,1990;4(2) : 92.
14. Yasunori E,Shunji K,Motofumi Y,et al. Hyperthermia enhances the i9nhibition of tumor growth by 1-(2-tetrahydrofuryl)-5-Fluorouracil/Uracil(1:4)in tumorsin mice and humans.Cancer,1992;70 : 1177.
15. 宁守诚,张锡泽.恶性肿瘤加热治疗的进展.中国肿瘤临床,1986;13(4) : 220.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

EFFECTS OF HYPERTHERMIA COMBINED WITH MITOMYCIN,5-FLUOROURACIL IN VITRO ON HUMAN GASTRIC CARCINOMA CELL

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