The model of acut hemorrhagic necrotizing pancreatitis(AHNP)was produced by retrograde injection of 3% sodium taurocholate into the biliopancreatic duct.48rats with AHNP were treated with Tanshin by subcutaneous injection(100mg/100g body weight,q12h,tanshin group),48 rats with AHNP without any treatment as control(control group).The resule showed that in the control group,there were severe hemorrhage,necroses and the lesions of microvascular,the activity of pancreatic enzyme in serum increased significantly(P lt;0.01)at 6h,after 12h the activities of those pancreatic enzymes decreased gradually, the lesions of microvascular and histology were becoming severer.In the Tanshin group,at 24h the lesions of microvascular and histology of the pancreas were modified significantly (P lt;0.05).These results suggest that the lesion of microcirculation play an important role in the later AHNP,and Tanshin has some effects on the AHNP by modifying the microcirculation of the pancreas.
Citation：
Fan Linjun,Gu Hongguang,Wang Aochuan.. EFFECT OF MICROCIRCULATION LESION ON ACUT HEMORRHAGIC ENCROTIZING PANCREATITIS OF ARTS AND THERAPEUTIC EFFECT OF TANSHIN. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1997, 4(1): 7-10. doi:
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- 1. Steinberg WM,Schlesselman SE.Treatment of acute pancreatitis:comprison of animal and human studies.Gastroenterology,1987;93:1420.
- 2. Aho HJ,Koskensalo SM-L,Nevalainen TJ.Experimental pancreatitis in the rat,sodium taurocholate-induced acute hemorrhagic pancreatitis.Scand J Gastroenterol,1980;15:411.
- 3. 程迅生,迟彦邦,祁佐元.慢性胆道梗阻时肝脏血流量及微血管床变化.中华外科杂志.1992;30(12):751.
- 4. Friess H.Standards in monitoring acute experimental pancreatitis.Eur Surg Res,1992;24(suppl 1):1.
- 5. 陈思锋,吴中立.体液和组织液磷脂酶A2的简便快速测定法.第二军医大学学报,1989;10(3):254.
- 6. Kyogoku T,Manabe T,Tobe T.Role of ischemia in acute pancreatitis:hemorrhagic shock converts edematous pancreatitis to hemorrhagic pancreatitis in rats. Dig Dis Sci,1992;37:1409.
- 7. Pfeffer RB,Lazzarini-Robertson A,Safadi D,et al.Gradations of pancreatitis,edematous,through hemorrhagic,experimentally produced by controlled injection of microspheres into blood vessels in ogs.Surgery,1962;51:764.
- 8. 张建新,黄?魁,伍福乐.复方丹参对急性胰腺炎大鼠胰腺血流量的影响及其治疗作用.中华实验外科杂志,1989;6(4):168.
- 9. Niederau C,Luthen R,Niederau MC,et al.Acute experimental hemorrhagic-necrotizing pancreatitis induced by feeding a choline-deficient,ethionine-supplemented diet.Eur Surg Res,1992;24(suppl 1):40.
