We determined the whole process of lipoprotein metabolism during the formation of gallstone in rabbit model of calcium bilirubinate cholangiolithiasis.The main results included:the concentrations of free cholesterol and HDL3cholesterol obviously increased in all experimental groups while HDLcholesterol,HDL2cholesterol decreased,the activities of lecithincholesterol acytransferase(LCAT) and the Bmax of HDLreceptor in hepatic cell centrations of glycocholic acid,glycodeoxychdic acid and total bile acid in the bile decreased obviously in experimental groups,the levels of LDLcholesterol,vLDLcholesterol in the serum and total cholesterol,triglyceride in the hepatic tissue were not significant differences in all groups.According to the above results,it may be concluded that:there were disorders of reduced HDL biosynthesis and its mature process caused by decreasing of LCAT activity during the formation of the gallstones caused by the bile duct obstruction and infection.Meanwhile,the Bmax of the HDLreceptor of the hepatic cell membrane decreased.Therefore,there were disorders of reverse cholesterol transport in many aspects.These factors together with other lithogenic elements probably promote the formation of the calcium bilirubinate gallstones.
Citation: 程南生,朱精强,吴沙沙,李宁,张明义,姚有贵,刘嘉林,林琦远,肖路加. THE REVERSE DISORDER OF CHOLESTEROL IN THE FORMATION OF CALCIUM BILIRUBINATE GALLSTONE IN RABBIT. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1997, 4(4): 197-200. doi: Copy