Hemodynamic changes of systemic and portal vein flow and regulation of indomethacin have been studied in 73 patients with obstructive jaundice(group A)and 39 cases with simple gallbladder stones(guoup B).Obstructive jaundice was subgrouped into group A1(noindomethacin administration),group A2(preoperative administration of indomethacin),group A3(postoperative administration of indomethacin),and group A6(senile obstructive jaundice).Of them group A1 was subgrouped into group A4(malignant obstruction)and group A5(benign obstruction)again.The results showed that the stroke volum(SV),cardiac output(CO)and cardiac index (CI)were higher in each group of obstructive jaundice than those in group B(P<0.01),and the mean artery pressure (MAP),stroke vessel resistance (SVR)and portal vein blood flow(PVF)were lower in each group of obstructive jaundice than those in group B(P<0.01).The MAP,SVR and PVF in group A2 and group A3 showed better improvement than those in other subgroups,but as compared with group B there were significant differences (P<0.01).The authors consider that indomethacin can improve the circulation function,PVF and liver function in patients with obstructive jaundice.
Citation: 方驰华,戴永贵,郑晓辉,郭光志. THE HEMODYNAMIC CHANGES ON SYSTEMIC AND PORTAL VEIN FLOW AND REGULATION WITH INDOMETHACIN IN OBSTRUCTIVE JAUNDICE. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1997, 4(4): 217-220. doi: Copy