A STUDY OF CHROMOSOMAL ABNORMALITY IN COLORECTAL CARCINOMA_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of General Surgery,First Affiliated Hospital,West China University of Medical Sciences,Chengdu 610041;

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Colorectal cancer; Cytogenet; Chromosome; Prognosis

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Cytogenetic study of 18 colorectal carcinomas confirmed the extensive heterogeneity and the complexity of the karyotypic picture in this tumor.Karyotypic analysis showed that chromosomes 7 and 3 were of the highest chromosomal gaining frequencies(72%,66%) and chromosomal losses were shown in chromosome 17(50%),chromosome5(44%) and chromosome 18(33%).The structual rearrangements frequently involved were 17p(78%),5q(61%),6q,7q,8p,12q,2p,etc.A great number of marker chromosomes and polyploid chromosomes had bad prognosis relatively.According to these results,we conclude that chromosomes 17,5,and 18 may play an important role in the evolution of colorectal cancer.

Citation： Li Li,Yan Lvnan,Wu Yantao,et al.. A STUDY OF CHROMOSOMAL ABNORMALITY IN COLORECTAL CARCINOMA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1996, 3(4): 193-195. doi: Copy

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1. Delattre O,Law DJ,Remuikos Y,et al.Multiple genetic alterations in distal and proximal colorectal cancer.Lancet,1989;2:353.
2. Muleris M,Salmon RJ,Dutrillaux B.Cytogenetics of colorectal adenocarcinomas.Cancer Genet Cytogenet,1990;46:143.
3. 邱红明.遗传性非息肉病性大肠癌分子病理学研究进展.国外医学遗传学分册,1995;4:176.
4. Alan W.Biochemical markers for colorectal cancer.Surg Clin Nor Am,1993;73:1.
5. Wang LM,Patel V,Ghosh L,et al.Mutation in the nm23 gene is associated with metastasis in colorectal cancar.Cancer Res,1993;53:717.
6. Ookawak,Sakamoto M,Hirohashi S,et al.Concordant p53 and Dcc alterations and allelic losses on chromosomes 17p and 18q associated with liver metastasis of colorectal carcinomas.Int J Cancer,1993;53:382.
7. Marx J.A challenge to p16 gene as a major tumor suppressor.Science,1994;264:1846.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

A STUDY OF CHROMOSOMAL ABNORMALITY IN COLORECTAL CARCINOMA

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