The somatostatin levels in serum, cancer tissue and its adjacent mucosas were measured in 43 patients with large intestine carcinoma(LIC). The results showed that the somatostatin level in serum of patients with LIC before operation was obviously lower than that in the control group (P lt;0.001)and after radical operation, it was markedly higher than the preoperative levels(P lt;0.01), but still lower than the control value(P lt;0.001). The somatostatin level in cancer tissue was evidently lower than that in its adjacent mucosas(P lt;0.001)and in normal mucosa(P lt;0.001). There was no significant correlation between the somatostatin level in serum or carcinoma tissue and Duke’s stage or pathological types of the carcinoma tissue. The results indicate that the somatostatin has a negative modulating effect on the growth of large intestine carcinomas, thus provides an experimental basis for the treatment of large treatment of large intestine carcinomas with drugs such as somatostatin.
Citation：
He Shuangwu,Li Jiaqi,Li Yibin,et al.. THE CLINICAL SIGNIFICANCE OF MEASUREMENT OF SOMATOSTATIN LEVELS IN SERUM AND CANCER TISSUE OF PATIENTS WITH LARGE INTESTINE CARCINOMA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1996, 3(4): 208-210. doi:
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- 1. Smith JP,Solomom TE.Effects of gastrin proglumide and somatostatin on growth of human colon cancer.Gastroenterology,1988;95:1941.
- 2. 刘文忠,江绍基,肖树东.胃肠激素和消化系肿瘤.基础医学与临床,1992;12:12.
- 3. Miller GV,Farmery SM,Woodhouse LF,et al.Somatostatin binding in normal and malignant human gastrointestinal mucosa.Br J Cancer,1992;66:391.
- 4. Damage CS,Hairi A,Karsenty L,et al.Somatostatin action in tumor models.Metabalism,1992;41:11.
- 5. Radulovic S,Schally AV,Reile H,et al.Inhibitory effects of antagonisis of bombesin/gastrin releasing peptide and somatostatin analog(RC-160)on growth of HT-29 human colon cancers in nude mice.Acta Oncol,1994;33:693.
- 6. Itzeu BD,Lolova I,Davidoff M.Immunocytochemical and electromicroscopical data on the differentiation of somatostatin-cantaining cells in human large intestine.Anat Anz Jena,1988;166:77.
