THE STUDY OF CORRELATION BETWEEN THE EXPRESSION STATE OF CARCINOEMBRYONIC ANTIGEN AND BIOLOGICAL BEHAVIOR OF GASTRIC CANCER TISSUE_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

Department of General Surgery, First Affiliated Hospital, Zhejiang Medical U-niversity, Hangzhou 310003;

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Keywords：

Carcinoembryonic antien; Gastric Cancer; Biological behavior

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Carcinoembryonic antigen (CEA)was measured with ABC immunohistochemistry method in fourty-one gastric cancer tissues and sixty-six tissue from normal stomach and gastric benign lesions. The study revealed that the reactive signals in the former were ber than those in the latter. Simultaneously, CEA localized mainly in the cytoplasm or stroma in the cancerous tissue, but in normal gastric tissue or benign gastric lession, CEA distributed mainly in the margin of gland with gastric depression or membranous type. The result also revealed that the distribution patterns of ECA were linked with the cell growth types and infiltrating of gastric cancer. The authors consider that the expression state of CEA in gastric cancer is correlated with its biological behavior, and distribution patterns of CEA are more clinically significant than reactive intensities in the tissue. Patients have different prognosis with different CEA distribution patterns in tissue though their pathological types and TNM stages are the same.

Citation： Liang Tingbo,ZhengShusen,Sun Yiguo,et al.. THE STUDY OF CORRELATION BETWEEN THE EXPRESSION STATE OF CARCINOEMBRYONIC ANTIGEN AND BIOLOGICAL BEHAVIOR OF GASTRIC CANCER TISSUE. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1996, 3(3): 156-159. doi: Copy

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2.	Kojima O, Ikeda E, Uehara Y,et al. Correlation between CEA in gastric cancer tissue and survival of patient with gastric cancer .Gann, 1984；75(3) :230.
3.	Wiggers T,Arends JW, Verstijnen C,et al. Prognostic signigicance of CEA immunoreactivity patterns in large bowel carcinoma tissue .Br J Cancer, 1986；54(3) :409.
4.	Davidson BR,Sams VR,Styles J,et al. Comparative study of carcinoembryonic antigen and epithelial membrane anti gen expression in normal colon,adenomas and adenocarcinomas of the colon and rectum .Gut, 1989；30(9) :1260.
5.	Hamada Y, Yamamura M, Hioki K, et al. Immunohistochemical study of CEA in patients with colonreetal cancer: correlation with plasma CEA levels .Cancer, 1985； 55(1) :137.
6.	张荫昌.胃病理及胃黏膜活检.第1版.沈阳：辽宁科学技术出版社，1988：82.
7.	Motoyamao T, Watanabe H. CEA production in human gastric cancer lines in vitro and in nude mice .Gann, 1983； 74(5) :679.
8.	Nagura H, Tsutsumi Y, Shioda Y, et al. Immunohistochemistry of carcinomas and associated diseases Novel distribution of CEA and secretory complement in the surface of gastric cancer cells .J Histo Cyto, 1983；31(1A) :193.
9.	Kiyama T,0nda M,Tokunaga A,et al. Changes in serum and tissue CEA with growth of human gastric cancer xenograft in nude mice .Jap J Can Res, 1990； 81(1) :58.
10.	Kiyama T. Serum CEA levels in patients with gastric carcinoma correlate with the tumorigenicity of their xenograft in nude mice .Jap J Surg, 1991； 21(1) :32.
11.	Jessup JM, Giavazzi R, Campbell D,et al. Growth potential of human colonrectal carcinoma in nude mice: association with the preoperative serum concentration of carcinoembryonic antigen in patients .Cancer Res, 1988；48(6) :1689.
12.	Benchinol S, Fuks A, Jothy S, et al. Carcinoembryonic antigen,a human tumor marker, functions as an intercel luar adhension molecule .Cell, 1989； 57(2) :327.
13.	Pignatelli M,Durbin H,Bodmer WF. Carcinomembryonic antigen functions as an accessory adhension molecule mediating colon epithelial cell-collagen interaction .Pro Natl Acad Sci, 1990；87(4) :1541.

1. 徐光炜.胃癌.第1版.北京：人民卫生出版社，1987：289～300.
2. Kojima O, Ikeda E, Uehara Y,et al. Correlation between CEA in gastric cancer tissue and survival of patient with gastric cancer .Gann, 1984；75(3) :230.
3. Wiggers T,Arends JW, Verstijnen C,et al. Prognostic signigicance of CEA immunoreactivity patterns in large bowel carcinoma tissue .Br J Cancer, 1986；54(3) :409.
4. Davidson BR,Sams VR,Styles J,et al. Comparative study of carcinoembryonic antigen and epithelial membrane anti gen expression in normal colon,adenomas and adenocarcinomas of the colon and rectum .Gut, 1989；30(9) :1260.
5. Hamada Y, Yamamura M, Hioki K, et al. Immunohistochemical study of CEA in patients with colonreetal cancer: correlation with plasma CEA levels .Cancer, 1985； 55(1) :137.
6. 张荫昌.胃病理及胃黏膜活检.第1版.沈阳：辽宁科学技术出版社，1988：82.
7. Motoyamao T, Watanabe H. CEA production in human gastric cancer lines in vitro and in nude mice .Gann, 1983； 74(5) :679.
8. Nagura H, Tsutsumi Y, Shioda Y, et al. Immunohistochemistry of carcinomas and associated diseases Novel distribution of CEA and secretory complement in the surface of gastric cancer cells .J Histo Cyto, 1983；31(1A) :193.
9. Kiyama T,0nda M,Tokunaga A,et al. Changes in serum and tissue CEA with growth of human gastric cancer xenograft in nude mice .Jap J Can Res, 1990； 81(1) :58.
10. Kiyama T. Serum CEA levels in patients with gastric carcinoma correlate with the tumorigenicity of their xenograft in nude mice .Jap J Surg, 1991； 21(1) :32.
11. Jessup JM, Giavazzi R, Campbell D,et al. Growth potential of human colonrectal carcinoma in nude mice: association with the preoperative serum concentration of carcinoembryonic antigen in patients .Cancer Res, 1988；48(6) :1689.
12. Benchinol S, Fuks A, Jothy S, et al. Carcinoembryonic antigen,a human tumor marker, functions as an intercel luar adhension molecule .Cell, 1989； 57(2) :327.
13. Pignatelli M,Durbin H,Bodmer WF. Carcinomembryonic antigen functions as an accessory adhension molecule mediating colon epithelial cell-collagen interaction .Pro Natl Acad Sci, 1990；87(4) :1541.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

THE STUDY OF CORRELATION BETWEEN THE EXPRESSION STATE OF CARCINOEMBRYONIC ANTIGEN AND BIOLOGICAL BEHAVIOR OF GASTRIC CANCER TISSUE

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