Thirty two surgical patients with liver disease (hepatocelluar carcinoma 16, liver cirrhosis 8, obstructive jaundice 8) were studied. All of them were randomly divided into three groups for administration of different kinds of TPN during the postoperative period [group Ⅰ (TPN without fat emulsion), group Ⅱ (TPN with fat emulsion, 1g/kg body weight/day of fat), group Ⅲ (TPN with fat emulsion 2g/kg body weight/day of fat )]. Their liver function test, glucose, lipid metabolism were examined and compared during the period of TPN. Result: ①TB, ALT and AST decreased in group Ⅱ and group Ⅲ (P lt;0.05), but increased in group Ⅰ (P lt;0.05). ②The blood glucose and insulin levels were normal in group Ⅱ and groupⅢ, but showed hyperglycemia and hyperinsulinemia in group Ⅰ (P lt;0.05). ③The serum lipid, lipoprotein, apoliprotein level and LCAT activity returned to normal 6 days after operation in group Ⅱ (P lt;0.05), but not in group Ⅰ and groupⅢ (P lt;0.05). Conclusion: ①TPN with fat emulsion for surgical patients with liver disease can make more improvement on hepatic functions than TPN without fat emulsion. ②1g/kg body weight/day of fat dosage may be suitable for the patients during the period of postoperative TPN.

Citation： Li Yinglai,Zheng Zhaoxu,Peng Bing,et al.. INFLUENCE OF FAT EMULSION ON LIPID METABOLISM OF SURGICAL PATIENTS WITH LIVER DISEASE. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1996, 3(2): 96-99. doi: Copy