In a series of experiments on rats,we have observed that the tensile strength and hydroxyproline content of left colonic anastomosis presented the lowest level on the 3rd and 4th postoperative days. Aprotinin,dimethyl sulfoxide,superoxide dismutase and vitamin A could improve the early coures of healing of colonic anastomosis;hydroxycortisone could retard the early course of healing of anastomosis and vitamin A antaonize the deleterious effect as mentioned above. Perioperative chemotherapy did not impair the early coures of healing of colonic anastomosis. The primary rasection and anastomosis of left colon for complete obstruction could be safety done if colonic content was decompressed before performing anastomosis and abdominal cavity was irrigated with antibiotic solutions afterwards. The mechanism of some factors influencing the healing of colonic anastomosis is discussed.
Citation：
Han Wenmiao,Wang Ziwei,Zhang Wei,et al.. AN EXPERIMENTAL STUDY OF FACTORS CONTRIBUTING TO LEAKAGE OF COLONIC ANASTOMOSES. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1995, 2(3): 136-139转封三. doi:
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.Hallett MB.Shandall A,Young HL.Mechanism of protection against"reperfusion injury"by aprotinin:roles of polymorphonuclear leucocytes and oxygen radicals.Bioch Phar,1985;34:1757.
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.Latner AL,Longstaff E,Pradhan K.Inhibition of malignant cell invasion in vitro by a proteinase inhibitor.Br J Cancer,1973;27:460.
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| 8. |
.Mc Cord JM.The superoxide free radical:its biochemistry and pathophysiology.Surgery,1983;94:412.
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| 9. |
.Hogstrom H,Haglund U,Zederfeldt B.Benefical effect on intestinal anastomoses of S-2441,a synthethic kallikrein-kinin antagonist.Experimental studies in the rat.Am J Surg,1985;150:312.
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.Schrock TR,Deveney CW,Dunphy JE.Factors contributing to leakage of colonic anastomoses.Ann Surg,1973;177:513.
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.Irvin TT.Collagen metabolism in infected colonic anastomosis.SGO,1976;143:220.
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| 12. |
.Houston KA,McRitchie DI,Rotstein OD.Tissue plasminogen activator reverses the deleterious affect of infection of colonic would healing.Ann Surg,1990；211:130.
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| 13. |
.Smith SRG,Conndly JC,Cilmore OJA.The sffect of faecal loading on colonic anastomotic healing.Br J Surg,1983;70:49.
|
| 14. |
.Hawley PR,Faulk WP.A circulatory collagenase inhibitor.Br J Surg,1970;57:900.
|
- 1. .Pittman DM,Smith LE.Complications of colostomy closure.Dis Colon Rect.1985;28:836.
- 2. .Fielding LP,Stewart-Brown S,Blesovsky L,et al.Anastomotic integrity after operations for large-bowel cancer:A multicentre study.Br Med J, 1980;281:411.
- 3. .八木固夫，血清过酸化脂质の测定とその临床的意义，临床病理，1982；29:221.
- 4. .Hogstrom H,Haglund U.Neutropenia prevents decrease in strength of rat intestinal anastomosis: Partial effect of oxygen free radical scavengers and allopurinol.Surgery,1986;99:716.
- 5. .Shandall AA,Williams GT,Hallett MB,et al. Colonic healing:a role for polymorphonuclear leucocytes and oxygen radical production.Br J Surg,1986;73:225.
- 6. .Hallett MB.Shandall A,Young HL.Mechanism of protection against"reperfusion injury"by aprotinin:roles of polymorphonuclear leucocytes and oxygen radicals.Bioch Phar,1985;34:1757.
- 7. .Latner AL,Longstaff E,Pradhan K.Inhibition of malignant cell invasion in vitro by a proteinase inhibitor.Br J Cancer,1973;27:460.
- 8. .Mc Cord JM.The superoxide free radical:its biochemistry and pathophysiology.Surgery,1983;94:412.
- 9. .Hogstrom H,Haglund U,Zederfeldt B.Benefical effect on intestinal anastomoses of S-2441,a synthethic kallikrein-kinin antagonist.Experimental studies in the rat.Am J Surg,1985;150:312.
- 10. .Schrock TR,Deveney CW,Dunphy JE.Factors contributing to leakage of colonic anastomoses.Ann Surg,1973;177:513.
- 11. .Irvin TT.Collagen metabolism in infected colonic anastomosis.SGO,1976;143:220.
- 12. .Houston KA,McRitchie DI,Rotstein OD.Tissue plasminogen activator reverses the deleterious affect of infection of colonic would healing.Ann Surg,1990；211:130.
- 13. .Smith SRG,Conndly JC,Cilmore OJA.The sffect of faecal loading on colonic anastomotic healing.Br J Surg,1983;70:49.
- 14. .Hawley PR,Faulk WP.A circulatory collagenase inhibitor.Br J Surg,1970;57:900.
