Forty-six patients with advanced gastric cancer were investigated. 25 patients were randomized to receive intraperitoneal hyperthermic (43℃) hypotonic perfusion with high dose cis-diamminedichloroplatinum (60-200mg/m2 body surface) and sodium thiosulfate intraveneously (7.5g/m2 body surface). The time of the intraperotineal perfusion was 30 minutes with the total volume of the perfusate of 2500-3000ml. 21 patients were only operated. The sex ,age macro-or microscopic serosal invasion, and histologic type of two groups were similar and comparatible. We found no cancer cell in nine paients with positive intraperitoneal free cancer cell in the treated group. The postoperative 1-year survival rate of patients in the treated group (96.00%) was significantly higher than that of the random control group (48.54%), Ｐ＜0.01. The postoperative 1 1/2year survival rate in the treated group (68.88%) was also higher than that of the control group (40.00%), however, with no significant difference (Ｐ＞0.05). No serious myelosuppression, kindley,liver, and peripheral nerve damage, and other complications were found. The results indicated that this therapy is reasonably safe and could be a prophylactic theapy for the peritoneal recurrence after radical gastrectomy, which should be further investigated.
Citation：
Chen Zhixing,Peng Desu,Zheng Jixiang.. A CLINICAL RANDOMIZED TRIAL OF INTRAOPERATIVE TWO-ROUTE CHEMOTHERAPY WITH HIGH DOSE CIS-DIAMMINEDICHLOROPLATINUM IN PATIENTS WITH ADVANCED GASTRIC CANCER. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1995, 2(2): 84-86. doi:
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Kui Chi S, Fujimoto S, Dkui K. Experimental study of heatinduced total cellular killing of human gastric cancer cells with particular reference to the thermal dose required to achieve total cellular killing. Jpn J Cancer Clin, 1991;37(5):500.
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陈俊青.低渗液、温热对体外培养胃癌细胞系MGC-803杀伤效应的实验研究.中国医科大学学报，1990；19(4)：269.
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- 1. Fujimoto S, Shretha RD, Kokubun M. Intraoperationeal hyperthermic perfusion combined with surgery effective for gastric cancer patients with peritoneal seeding. Ann Surg, 1988;208:36.
- 2. Howell SB, Pfeifle CE, Wang WE. Intraperitoneal cis-diamminedichloroplatinum with systemic thiosulfate protection. Cancer Res, 1983;43:1426.
- 3. 徐淑云.临床用药指南.合肥：安徽科学技术出版社，1989：8.
- 4. Howell SB, Richard A, Craig E. Intraperitoneal cisplatin with systemic thiosulfate protection. Ann Intern Med, 1982;97:805.
- 5. Howell SB, Kirmanis S, Licas WE. A phase trial of intraperitoneal cisplatin and etoposide for primary ovaran epithelial cancer. J Clin Oncol, 1990;8:137.
- 6. Mcvie TG. Tissue concetration of platinum after intraperitoneal cisplatinum administration in patients. Proc Am Assoc Cancer Res, 1985;26:162.
- 7. Spyper TL. The rationale behind intraperitoneal chemotherapy in gastraintestinal malignancies. Semin col, 1985;13:23.
- 8. Los G, Smals OA, Van Vugt MJ. A rationale behind intraperitoneal for carcoplatin treatment and abdominal hyperthermia in cancers restricted to the peritoneal cavity cancer Res, 1992;52:1252.
- 9. Kui Chi S, Fujimoto S, Dkui K. Experimental study of heatinduced total cellular killing of human gastric cancer cells with particular reference to the thermal dose required to achieve total cellular killing. Jpn J Cancer Clin, 1991;37(5):500.
- 10. 陈俊青.低渗液、温热对体外培养胃癌细胞系MGC-803杀伤效应的实验研究.中国医科大学学报，1990；19(4)：269.
