THE EFFECTS OF Na+,K+ CONTENT IN HX SOLATION ON RATS’S LIVER PRESERVATION_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of Surgery, The First Affiliated Hospital, West China University of Meedical Sciences,Chengdu 610041;

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HX solution with high potassium and ow sodium; HX solution with high sodium and liw potassium Rat’s liver preservation

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The effects on rat’s liver preservation using HX solation with high potassium and low sodium or HXm solution with high sodium and low potassium were studied with isolated perfusion of rat livers (IPRL). Sixty inbred Wistar rats were randomly divided into group HX (preserved with HX solution, n=30) and group HXm (preserved with HXm solution,n=30). The preservation effects of the storage solutions were assessed by measuring the sinunoidal lining cell mortality (SLCM), the Krebs-hense-leit perfusate ketone bidy ratio (PKBR), the hepatic sugar release (SL), and the hepatic tissue water content (HTWC). The results showed that there no significant differences between the two storage solutions after 6 hours preservation. If the preserved time was prolonged to 12 hours or more, the effect of rat’s liver preservation using HX solution were much superior to those using HXmsolutin.

Citation： Zhang Ruimin,Wu Heguang,Sheng Wenlu,etal.. THE EFFECTS OF Na+,K+ CONTENT IN HX SOLATION ON RATS’S LIVER PRESERVATION. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1994, 1(2): 67-70. doi: Copy

1.	张锐敏，沈文律，吴言涛等.自制灌注液—HX液延长大鼠肝脏有效保存时间的初步研究.见：第二届全国器官移植学术会议编.第二届全国器官移植学术会议论文汇编.武汉：同济医科大学，1993：69.
2.	Belinsky SA, Popp JA, Kauffman FC, et al. Trypan blue uptake ad a new method to study zonal hepatotoxicity in the perfused liver. J Pharmacol Exp Ther, 1984;230:755.
3.	Collins GM, Bravo-Shugarman M, Teraski PI. Kidney preservation for transplatation-initial perfusion and 30 hours’ ice storage. Lancet, 1969;2:1229.
4.	Moen J, Claesson K, Piennar H, et al. Preservation of dog liver, kidney, and pancreas using the Belzer-UW solution with high-sodium and low-potassium content. Transplantation,1989;47:940.
5.	Rao PN, Walsh Makowka L, et al. Inbition of free radical generation and improved survival by protection of the hepatic mictocascular endothelium targeted erythrocytes in orthotoic rat liver transplantation. Transplantation,1990;49:1055.
6.	Howard TK, Goran B, Lintmalm G, et al. The influence of preservation injury on rejection in the hepatic transplant recipient. Transplantation, 1990;49:103.
7.	Tashiro S, Kawamoto K, Hayashida N, et al. Evaluation of arly graft function in orthotopic liver transplants in dogs. Transplant Proc,1989;21:1344.
8.	Kobayashi T, Sumimoto R, Shimada H, et al. Effect of sugars in the preservation solution on liver storage in rats. Cryobiology,1991;28:425.

1. 张锐敏，沈文律，吴言涛等.自制灌注液—HX液延长大鼠肝脏有效保存时间的初步研究.见：第二届全国器官移植学术会议编.第二届全国器官移植学术会议论文汇编.武汉：同济医科大学，1993：69.
2. Belinsky SA, Popp JA, Kauffman FC, et al. Trypan blue uptake ad a new method to study zonal hepatotoxicity in the perfused liver. J Pharmacol Exp Ther, 1984;230:755.
3. Collins GM, Bravo-Shugarman M, Teraski PI. Kidney preservation for transplatation-initial perfusion and 30 hours’ ice storage. Lancet, 1969;2:1229.
4. Moen J, Claesson K, Piennar H, et al. Preservation of dog liver, kidney, and pancreas using the Belzer-UW solution with high-sodium and low-potassium content. Transplantation,1989;47:940.
5. Rao PN, Walsh Makowka L, et al. Inbition of free radical generation and improved survival by protection of the hepatic mictocascular endothelium targeted erythrocytes in orthotoic rat liver transplantation. Transplantation,1990;49:1055.
6. Howard TK, Goran B, Lintmalm G, et al. The influence of preservation injury on rejection in the hepatic transplant recipient. Transplantation, 1990;49:103.
7. Tashiro S, Kawamoto K, Hayashida N, et al. Evaluation of arly graft function in orthotopic liver transplants in dogs. Transplant Proc,1989;21:1344.
8. Kobayashi T, Sumimoto R, Shimada H, et al. Effect of sugars in the preservation solution on liver storage in rats. Cryobiology,1991;28:425.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

THE EFFECTS OF Na+,K+ CONTENT IN HX SOLATION ON RATS’S LIVER PRESERVATION

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