We determined estrogen receptor (ER), estradiol (E2) and testosterone (T) in the tissue of 50 gastric carcinomas ans 20 benign stomach diseases. The result showed that the positive rate of ER was 32.0% in gastric cancerous tissue, in which the poorly-differentiated type was higher than that of the well-differentiated type (P lt;0.05)，and still higher in BorrmannⅢ、Ⅳ types than in Borrmann Ⅰ、Ⅱ types (P lt;0.01). The determination of Er is significant for the estimation of prognosis ans endocrinal therapy after operation. E2 content showed no obvious difference betweenn gastric carcinoma, benign somach diseases ans normal gastric mucose, but T level and T/E2 ratio in gastric cancer were much higher than those in benign stomach diseases and normal gastric mucosa (P lt;0.05). IT suggested that the imbalance of E2 and T contents may related the occurence of gatric carcinoma. The E2 and T level showed no obvious difference between ER+ and ER- in gastric cancerous tissue.
Citation：
He Shuangwu,Tu Yongjiu,Xie Shangkui.. CLNICAL SIGNIFICANCE OF DETERJIATION OF ESTROGEN RECEPTOK, ESTRADIOL AND TESTOSTERONE IN GASTRIC CARCINOMATOUS TISSUE. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1994, 1(2): 84-87. doi:
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Tokunaga A, Nishi, Matsukura N, et al. Estrogen and progestterne receptors in gastric cancer. Cancer,1986;57:136.
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Harrison JD, Jones JA, Ellis IL, et al. A roandomized controlled study of adjuvant tamoxigen in the treatment of gatric carcinoma. Br J Surg, 1987;74:1143.
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Harrison JD, Jones JA, Ellis IO, et al. Oestrogen receptor D5 antibody is an independency negetive progrostic factor in gastric cancer. Br J Surg, 1991;78:334.
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Kitaoka H. Sex hormone dependency in diffuse xarcinoma of the stomach and rsults of chmoendocrine therapy.Gan-No-Rinsho, 1984;30:841.
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陆家齐.抗雌激素药物对晚期消化道肿瘤的疗效.解放军医学情报，1991；5：841.
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| 6. |
Lowry OH, Rosebrough NJ, Garr AL, et al. Protein measurement with the folin phenol reagent. J Biol Chem, 1951;193:265.
|
| 7. |
Joanhnion KB, Simplifies sxatxhard-plot assay for estrogen receptor in human breast tumor. Clin Chem. 1975;21:1725.
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马宝丽，肖祥熊主编.医学免疫学，第1版，武汉：同济医科大学出版社，1987：181.
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| 9. |
朱斌，郑扶民，何尔斯泰.胃癌雌激素受体的检测.中华肿瘤杂志，1991；13：430.
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| 10. |
Furukawa H, Iwanaga J, Hirattuka M, et al. Suppressive effect of sex hormone on spreeding of stomach cancer. Gan-To-Kagaku-Ryoho, 1989;16:3691.
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| 11. |
Furukawa H, Iwanaga J, Koyama H, et al. Effect of sex hormone on xarcinogenesis in the stomachs of rats. Cancer Res, 1982;42:5181.
|
| 12. |
INutsuka S, Kodama Y, Natsuda Y, et al. Serum testosterone level of patients with gastric carcimona before and afer gastrctomy. Cancer, 1986;58:2675.
|
| 13. |
Nishi K, Tokunaga A, Shimizu Y, et al. Immunohistochemical study of intracellular estradiol in human gatric cancer. Cancer, 1987;59:1328.
|
- 1. Tokunaga A, Nishi, Matsukura N, et al. Estrogen and progestterne receptors in gastric cancer. Cancer,1986;57:136.
- 2. Harrison JD, Jones JA, Ellis IL, et al. A roandomized controlled study of adjuvant tamoxigen in the treatment of gatric carcinoma. Br J Surg, 1987;74:1143.
- 3. Harrison JD, Jones JA, Ellis IO, et al. Oestrogen receptor D5 antibody is an independency negetive progrostic factor in gastric cancer. Br J Surg, 1991;78:334.
- 4. Kitaoka H. Sex hormone dependency in diffuse xarcinoma of the stomach and rsults of chmoendocrine therapy.Gan-No-Rinsho, 1984;30:841.
- 5. 陆家齐.抗雌激素药物对晚期消化道肿瘤的疗效.解放军医学情报，1991；5：841.
- 6. Lowry OH, Rosebrough NJ, Garr AL, et al. Protein measurement with the folin phenol reagent. J Biol Chem, 1951;193:265.
- 7. Joanhnion KB, Simplifies sxatxhard-plot assay for estrogen receptor in human breast tumor. Clin Chem. 1975;21:1725.
- 8. 马宝丽，肖祥熊主编.医学免疫学，第1版，武汉：同济医科大学出版社，1987：181.
- 9. 朱斌，郑扶民，何尔斯泰.胃癌雌激素受体的检测.中华肿瘤杂志，1991；13：430.
- 10. Furukawa H, Iwanaga J, Hirattuka M, et al. Suppressive effect of sex hormone on spreeding of stomach cancer. Gan-To-Kagaku-Ryoho, 1989;16:3691.
- 11. Furukawa H, Iwanaga J, Koyama H, et al. Effect of sex hormone on xarcinogenesis in the stomachs of rats. Cancer Res, 1982;42:5181.
- 12. INutsuka S, Kodama Y, Natsuda Y, et al. Serum testosterone level of patients with gastric carcimona before and afer gastrctomy. Cancer, 1986;58:2675.
- 13. Nishi K, Tokunaga A, Shimizu Y, et al. Immunohistochemical study of intracellular estradiol in human gatric cancer. Cancer, 1987;59:1328.
