Study of insulin and insulin receptor in asthma patients_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

 CHEN Yanwen , GAI Jun , HE Quanying

Department of Pulmonary Medicine，People’s Hospital，Peking University.Beijing，100044，ChinaCorresponding author：CHEN Yan-wen，E-mail：chenyw20032003@yahoo.com.cn;

Corresponding author：

CHEN Yanwen, Email: chenyw20032003@yahoo.com.cn

Keywords：

Bronchial asthma; Insulin; Insulin receptor

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Objection To investigate the changes of insulin and insulin receptor in asthma patients.Methods Forty asthma patients were allocated into two groups：20 newly diagnosed treatment–na iuml;ve mild-moderate asthma patients，20 mild-moderate persistent asthma patients treated with inhaled corticosteroid. 20 healthy volunteers were enrolled as normal control.Blood samples were obtained from 40 asthma patients and 20 healthy volunteers.Total and differential leukocyte counts,blood glucose concentration and serum insulin concentration were measured.The level of lymphocyte insulin receptor in peripheral blood were assayed by flow cytomertry.Pulmonary function were performed at the same time.Results The numbers of eosinophil in the two asthma groups were significantly higher than those in the normal control group [(4.04±2.57)% and (4.24±2.34)% vs (0.90±1.38)%，P lt;0.05)，the levels of insulin and insulin receptor in the treatment-na iuml;ve group were significantly higher than those in the control group [insulin：(13.00±5.20)mIU/L vs (10.08±3.79)mIU/L，P lt;0.05；insulin receptor：(2.59±3.11)% vs (0.99±0.62)%，P lt;0.05).Conclusion Insulin secretion and insulin receptor expression in asthma patients are increased in the presence of inflammation.

Citation： CHEN Yanwen,GAI Jun,HE Quanying. Study of insulin and insulin receptor in asthma patients. Chinese Journal of Respiratory and Critical Care Medicine, 2007, 6(1): 8-11. doi: Copy

1.	Dahlqvist G，Pattterson C，Soltesz G.Decreased prevalence of atopic diseases in children with diabetes.The EURODIAB Substudy 2 study Group.J Pediatrics，2000，137：470-474.
2.	Vianna EO，Garcia -Leme J.Allergen-induced airway inflammation in rats.Role of insulin.Am J Respir Crit Care Med，1995，151：809-814.
3.	Fortes ZB，Farsky SP，Oliveira MA，et al.Direct vital microscopic study of defective leukocyte-endothelial interaction in diabetes mellitus.Diabetes，1991，40：1267-1273.
4.	Fortes ZB，Garcia Leme J，Scivoletto R.Vascular reactity in diabetes mellitus：possible role of insulin on the endothelial cell.Br J Pharmacol，1984，83：635-643.
5.	Belmonte KE，Fryer AD，Costello RW.Role of insulin in antigen-induced airway eosinophilia and neuroal M2 muscarinic receptor dysfunction.J Appl Physiol，1998，85：1708-1718.
6.	Abrahamson EM.Asthma，diabetes mellitus and hyperinsulinism.J Clin Endocrinol，1941，1：402-406.
7.	HELANDER E.Asthma and diabetes.Acta Med Scand，1958，162：165-174.
8.	马艳良，何权瀛.胰岛素及胰岛素受体在大鼠变应性气道炎症中的作用.中华医学杂志，2005，85：3419-3424.
9.	中华医学会呼吸病学会哮喘学组.支气管哮喘防治指南（支气管哮喘的定义、诊断、治疗及教育和管理方案）.中华内科杂志，2003，42：817-822.
10.	Standardization of Spirometry，1994 Update.American Thoracic Society.Am J Respir Crit Care Med，1995，152：1107-1136.
11.	Solimena M，De Camille P.From Thl to Th2：diabetes immunotherapy shifts gears.Nat Med，1996，2：1311-1312.
12.	Haskell JF，Meezan E，Pillion DJ.Identification of the insulin receptor of cerebral microvessels.Am J Physiol，1985，248：E115-E125.
13.	Bar RS，Kahn CR，Koren HS.Insulin inhibition of antibody-dependent cytotoxicity and insulin receptors in macrophages.Nature，1977，265：632-635.
14.	Mineev VN，Bulatova Niu，Fedoseev GB.Erythrocyte insulin-reactive system and carbohydrate metabolism in bronchial asthma.Ter Arkh，2002，74：14-17.
15.	谢正福，何权瀛.链脲菌素性糖尿病大鼠模型对抗原引起的变应性气道炎症的影响.中日友好医院学报，2004，18：87-91.
16.	Fortes ZB，Farsky SP，Oliveria MA，et al.Direct vital microscopic study of defective leukocyte-endothelial interaction in diabetes mellitus.Diabetes，1991，40：1267-1273.
17.	Belmonte KE，Fryer AD，Costello RW.Role of insulin in antigen-induced airway eosinophilia and neuroal M2 muscarinic receptor dysfunction.J Appl Physiol，1998，85：1708-1718.
18.	de Pirro R，Bertoli A，Fusco A，et al.Effect of dexamethasone and cortisone on insulin receptors in normal human male.J Clin Endocrinol Metab，1980，51：503-507.
19.	Kato S，Itoh S，Miura Y，et al.Characterization of insulin receptors in primary cultures of quail (Coturnix coturnix japonica) oviduct cells.The level of insulin receptor is regulated by steroid and peptide hormones.Comp Biochem Physiol B，1990，97：783-791.
20.	张绍维，李浩，张尔强，等.氢化可的松和氟美松对人红细胞膜胰岛素受体的影响.中华内科杂志，1994，33：681-683.
21.	Goldstein DE，Konig P.Effect of inhaled beclomethasone dipropionate on hypothalamic-pituitary-adrenal axis function in children with asthma.Pediatrics，1983，72：60-64.
22.	丁会，王建国，卢连根.长期吸入糖皮质激素对支气管哮喘患者骨密度、血糖和血压的影响.白求恩医科大学学报，2000，26：632-633.
23.	冯涛，于艳，姜敏，等.长期吸入必可酮气雾剂对哮喘患者糖代谢的影响.中华现代临床医学杂志，2005，3：2163-2164.

1. Dahlqvist G，Pattterson C，Soltesz G.Decreased prevalence of atopic diseases in children with diabetes.The EURODIAB Substudy 2 study Group.J Pediatrics，2000，137：470-474.
2. Vianna EO，Garcia -Leme J.Allergen-induced airway inflammation in rats.Role of insulin.Am J Respir Crit Care Med，1995，151：809-814.
3. Fortes ZB，Farsky SP，Oliveira MA，et al.Direct vital microscopic study of defective leukocyte-endothelial interaction in diabetes mellitus.Diabetes，1991，40：1267-1273.
4. Fortes ZB，Garcia Leme J，Scivoletto R.Vascular reactity in diabetes mellitus：possible role of insulin on the endothelial cell.Br J Pharmacol，1984，83：635-643.
5. Belmonte KE，Fryer AD，Costello RW.Role of insulin in antigen-induced airway eosinophilia and neuroal M2 muscarinic receptor dysfunction.J Appl Physiol，1998，85：1708-1718.
6. Abrahamson EM.Asthma，diabetes mellitus and hyperinsulinism.J Clin Endocrinol，1941，1：402-406.
7. HELANDER E.Asthma and diabetes.Acta Med Scand，1958，162：165-174.
8. 马艳良，何权瀛.胰岛素及胰岛素受体在大鼠变应性气道炎症中的作用.中华医学杂志，2005，85：3419-3424.
9. 中华医学会呼吸病学会哮喘学组.支气管哮喘防治指南（支气管哮喘的定义、诊断、治疗及教育和管理方案）.中华内科杂志，2003，42：817-822.
10. Standardization of Spirometry，1994 Update.American Thoracic Society.Am J Respir Crit Care Med，1995，152：1107-1136.
11. Solimena M，De Camille P.From Thl to Th2：diabetes immunotherapy shifts gears.Nat Med，1996，2：1311-1312.
12. Haskell JF，Meezan E，Pillion DJ.Identification of the insulin receptor of cerebral microvessels.Am J Physiol，1985，248：E115-E125.
13. Bar RS，Kahn CR，Koren HS.Insulin inhibition of antibody-dependent cytotoxicity and insulin receptors in macrophages.Nature，1977，265：632-635.
14. Mineev VN，Bulatova Niu，Fedoseev GB.Erythrocyte insulin-reactive system and carbohydrate metabolism in bronchial asthma.Ter Arkh，2002，74：14-17.
15. 谢正福，何权瀛.链脲菌素性糖尿病大鼠模型对抗原引起的变应性气道炎症的影响.中日友好医院学报，2004，18：87-91.
16. Fortes ZB，Farsky SP，Oliveria MA，et al.Direct vital microscopic study of defective leukocyte-endothelial interaction in diabetes mellitus.Diabetes，1991，40：1267-1273.
17. Belmonte KE，Fryer AD，Costello RW.Role of insulin in antigen-induced airway eosinophilia and neuroal M2 muscarinic receptor dysfunction.J Appl Physiol，1998，85：1708-1718.
18. de Pirro R，Bertoli A，Fusco A，et al.Effect of dexamethasone and cortisone on insulin receptors in normal human male.J Clin Endocrinol Metab，1980，51：503-507.
19. Kato S，Itoh S，Miura Y，et al.Characterization of insulin receptors in primary cultures of quail (Coturnix coturnix japonica) oviduct cells.The level of insulin receptor is regulated by steroid and peptide hormones.Comp Biochem Physiol B，1990，97：783-791.
20. 张绍维，李浩，张尔强，等.氢化可的松和氟美松对人红细胞膜胰岛素受体的影响.中华内科杂志，1994，33：681-683.
21. Goldstein DE，Konig P.Effect of inhaled beclomethasone dipropionate on hypothalamic-pituitary-adrenal axis function in children with asthma.Pediatrics，1983，72：60-64.
22. 丁会，王建国，卢连根.长期吸入糖皮质激素对支气管哮喘患者骨密度、血糖和血压的影响.白求恩医科大学学报，2000，26：632-633.
23. 冯涛，于艳，姜敏，等.长期吸入必可酮气雾剂对哮喘患者糖代谢的影响.中华现代临床医学杂志，2005，3：2163-2164.

Chinese Journal of Respiratory and Critical Care Medicine

Study of insulin and insulin receptor in asthma patients

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