Objective To investigate the influence of chronic alcohol ingestion on the severity of acute lung injury (ALI) induced by oleic acid and lipopolysaccharide (LPS).Methods Thirty-two SD rats were randomly administrated with alcohol or water for 6 weeks，then instilled with oleic acid and LPS to induce ALI or with normal saline as control.Thus the rats were randomly divided into two injury groups [ethanol group and water group] and two control groups [ethanol group and water group] (n=8 in each group). PaO2,Wet to dry lung weight ratio (W/D)，levels of γ-glutamylcysteinylglycine (GSH) and malonaldehyde (MDA) in the lung tissue were measured.Results Compared to corresponding control groups，the PaO2 and GSH significantly decreased，and the lung W/D and MDA level were significantly increased in the injury groups (all P lt;0.05).In the injury groups，the changes of above parameters were more significant in the alcohol group than thoe in the water group (all P lt;0.05)，except the lung W/D with no significant difference.Conclusion Chronic ethanol ingestion was relevalent to oxidation/ antioxidation imbalance and more severe lung injury in rats with severe septic after trauma,which suggests that chronic alcohol abuse could increase the severity of acute lung injury.
Citation：
ZHU Minli,YU Senyang. Influence of chronic alcohol intake on acute lung injury in rats. Chinese Journal of Respiratory and Critical Care Medicine, 2007, 6(1): 49-51. doi:
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黄红娥，林昆.潮汕地区部分人群吸烟及饮酒情况调查.华南预防医学，2006，32：51-53.
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赵晓军，况怡，岳文彬.常州市农村居民健康知识、行为及需求调查.职业与健康，2006，22：1083-1084.
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陈超，罗有年，刘学兵，等.中国珠三角地区普通人群饮酒状况调查及相关因素分析.中国行为医学科学，2005，14：730-732.
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赵立中，张丽萍，沈艳荣，等.长春地区酒精依赖调查研究.中国药物滥用防治杂志，1996，4：17-20.
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Moss M，Parsons PE，Steinberg KP，et al.Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock.Crit Care Med，2003，31：869-877.
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李琦，钱桂生，张青，等.油酸-内毒素序贯致伤引起大鼠急性肺损伤的特点.第三军医大学学报，2004，26：856-858.
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Moss M，Bucher B，Moore FA，et al.The role of chronic alcohol abuse in the development of acute respiratory distress syndrome in adults.JAMA，1996，275：50-54.
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| 8. |
Brown LA，Harris FL，Bechara R，et al.Effect of chronic ethanol ingestion on alveolar type II cell：glutathione and inflammatory mediator-induced apoptosis.Alcohol Clin Exp Res，2001，25：1078-1085.
|
| 9. |
Burnham EL，Brown LA，Halls L，et al.Effects of chronic alcohol abuse on alveolar epithelial barrier function and glutathione homeostasis.Alcohol Clin Exp Res，2003，27：1167-1172.
|
| 10. |
Altavilla D，Marini H，Seminara P，et al.Protective effects of antioxidant raxofelast in alcohol-induced liver disease in mice.Pharmacology，2005，4：6-14.
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| 11. |
Terasaki PI，Yuge J，Cecka JM，et al.Thirty-year Trends in clinical kidney transplantation.Clin Transpl，1993，553-562.
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- 1. 黄红娥，林昆.潮汕地区部分人群吸烟及饮酒情况调查.华南预防医学，2006，32：51-53.
- 2. 赵晓军，况怡，岳文彬.常州市农村居民健康知识、行为及需求调查.职业与健康，2006，22：1083-1084.
- 3. 陈超，罗有年，刘学兵，等.中国珠三角地区普通人群饮酒状况调查及相关因素分析.中国行为医学科学，2005，14：730-732.
- 4. 赵立中，张丽萍，沈艳荣，等.长春地区酒精依赖调查研究.中国药物滥用防治杂志，1996，4：17-20.
- 5. Moss M，Parsons PE，Steinberg KP，et al.Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock.Crit Care Med，2003，31：869-877.
- 6. 李琦，钱桂生，张青，等.油酸-内毒素序贯致伤引起大鼠急性肺损伤的特点.第三军医大学学报，2004，26：856-858.
- 7. Moss M，Bucher B，Moore FA，et al.The role of chronic alcohol abuse in the development of acute respiratory distress syndrome in adults.JAMA，1996，275：50-54.
- 8. Brown LA，Harris FL，Bechara R，et al.Effect of chronic ethanol ingestion on alveolar type II cell：glutathione and inflammatory mediator-induced apoptosis.Alcohol Clin Exp Res，2001，25：1078-1085.
- 9. Burnham EL，Brown LA，Halls L，et al.Effects of chronic alcohol abuse on alveolar epithelial barrier function and glutathione homeostasis.Alcohol Clin Exp Res，2003，27：1167-1172.
- 10. Altavilla D，Marini H，Seminara P，et al.Protective effects of antioxidant raxofelast in alcohol-induced liver disease in mice.Pharmacology，2005，4：6-14.
- 11. Terasaki PI，Yuge J，Cecka JM，et al.Thirty-year Trends in clinical kidney transplantation.Clin Transpl，1993，553-562.
