Objective To evaluate the diagnostic value of brain natriuretic peptide (BNP) for cardiac dyspnea.Methods Plasma BNP levels were measured by radioimmunoassay in dyspnea patients with chronic heart failure (CHF) (n=52) or without CHF (n=30) and normal control group (n=28).Results The BNP level in dyspnea patients with CHF was significantly higher than that of dyspnea patients without CHF and normal control group [(649.80±141.72) pg/mL vs (59.08±18.60) pg/mL and (65.20±16.32) pg/mL，respectively,P lt;0.05].There was no significant difference of BNP level between dyspnea patients without CHF and normal group (P gt;0.05).The plasma BNP level elevated with the worsening of heart failure (NYHA Classiffication).The BNP level in dyspnea patients with CHF was negatively correlated with left ventricle ejection fraction (r=－0.673，P lt;0.001).The receiver operating characteristic (ROC) curve analysis showed that the area under the ROC curve (AUC) is 0.91(0.88-0.98，P lt;0.001) with a sensitivity of 87.2% and a specificity of 86.8% at the cutoff value of 206 pg/mL.Conclusion Measurement of plasma BNP is a rapid diagnostic method for cardiac dyspnea.
Citation：
YAO Guang,LAN Haiyun. Diagnostic significance of brain natriuretic peptide in cardiac dyspnea. Chinese Journal of Respiratory and Critical Care Medicine, 2007, 6(1): 52-54. doi:
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Copyright © the editorial department of Chinese Journal of Respiratory and Critical Care Medicine of West China Medical Publisher. All rights reserved
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吴彦，胡大一.B型脑钠素评价急性呼吸困难研究.中国医刊，2003，10：62-63.
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Mueller C，Laule-Kilian K，Christ A，et al.The use of B-type natriuretic peptide in the diagnosis of acute dyspnoea.Clin Lab，2005，51：5-9.
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黄培志，童朝阳，顾国荣，等.呼吸困难患者快速检测脑钠素的意义.上海医学，2005，28：61-63.
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曹向红，王凤芝，曹俊杰，等.血浆脑钠素在心源性和肺源性呼吸困难鉴别诊断中的价值.中国药物与临床，2004，4：116-119.
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Maisel AS，Krishnaswamy P，Nowak RM，et al.Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure.N Engl J Med，2002，347：161-167.
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| 11. |
陈协兴，洪华山，王一波，等.慢性心力衰竭患者血清脑利钠肽水平的变化及其临床意义.中华临床药理学与治疗学，2003，8：631-634.
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- 1. McDonagh TA，Robb SD，Murdoch DR，et al.Biochemical detection of left ventricular systolic dysfunction.Lancet，1998，351：9-13.
- 2. Cabanes L，Richaud-Thiriez B，Fulla Y，et al.Brain natriuretic peptide blood levels in the differential diagnosis of dyspnea.Chest，2001，120：2047-2050.
- 3. 陈协兴，洪华山，王一波，等.脑钠素在慢性心力衰竭诊断、预后评估中的价值.中国循环杂志，2003，18：434-436.
- 4. Krishnaswamy P，Lubien E，Clopton P，et al.Utility of B-natriuretic peptide levels in identifying patients with left ventricular systolic or diastolic dysfunction.Am J Med，2001，111：274-279.
- 5. Lubien E，DeMaria A，Krishnaaswamy P，et al.Utility of B-natriuretic peptide in detecting diastolic dysfunction：comparison with Doppler velocity recordings.Circulation，2002，105：595-601.
- 6. 吴彦，胡大一.B型脑钠素评价急性呼吸困难研究.中国医刊，2003，10：62-63.
- 7. Mueller C，Laule-Kilian K，Christ A，et al.The use of B-type natriuretic peptide in the diagnosis of acute dyspnoea.Clin Lab，2005，51：5-9.
- 8. 黄培志，童朝阳，顾国荣，等.呼吸困难患者快速检测脑钠素的意义.上海医学，2005，28：61-63.
- 9. 曹向红，王凤芝，曹俊杰，等.血浆脑钠素在心源性和肺源性呼吸困难鉴别诊断中的价值.中国药物与临床，2004，4：116-119.
- 10. Maisel AS，Krishnaswamy P，Nowak RM，et al.Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure.N Engl J Med，2002，347：161-167.
- 11. 陈协兴，洪华山，王一波，等.慢性心力衰竭患者血清脑利钠肽水平的变化及其临床意义.中华临床药理学与治疗学，2003，8：631-634.
