再次全肺灌洗治疗肺泡蛋白沉积症一例_Chinese Journal of Respiratory and Critical Care Medicine

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朱际平 , 郑玲 , 于力克

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Keywords：

全肺灌洗; 肺泡蛋白沉积症

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肺泡蛋白沉积症（PAP）是一种罕见的呼吸系统疾病，主要是由于肺泡腔中大量的嗜酸性富含脂质和蛋白质的物质沉积[1]，可分为先天性、继发性和获得性三类。目前PAP最有效的治疗是全肺灌洗[2]。多数文献报道的是对初次诊断的PAP患者的全肺灌洗治疗。2005年我们收治了1例PAP患者，经全肺灌洗治疗10个月后复诊，根据其影像学表现再次进行全肺灌洗治疗，现报告如下。

Citation： 朱际平,郑玲,于力克. 再次全肺灌洗治疗肺泡蛋白沉积症一例. Chinese Journal of Respiratory and Critical Care Medicine, 2007, 6(1): 68-69. doi: Copy

1.	Trapnell BC, Whitsett JA, Nakata K. Pulmonary alveolar proteinosis. N Engl J Med,2003，349:2527-2539.
2.	Beccaria M, Luisetti M, Rodi G,et al. Long-term durable benefit after whole lung lavage in pulmonary alveolar proteinosis.Eur Respir J,2004，23: 526-531.
3.	Ramirez J, Schultz RB, Dutton RE. Pulmonary alveolar proteinosis: a new technique and rationale for treatment. Arch Intern Med,1963，112:419-431.
4.	Goldstein LS, Kavuru MS, Curtis-McCarthy P, et al. Pulmonary alveolar proteinosis: clinical features and outcomes. Chest, 1998，114: 1357-1362.
5.	Richard A.Morris Manual of Clinical problems in pulmonary medicine 5th ed .天津：天津科技翻译出版公司,2003.524.
6.	蔡后荣，崔苏阳，金陵，等.体外循环膜氧合支持下全肺灌洗治疗肺泡蛋白沉积症一例并文献复习.中华结核和呼吸杂志，2005，28：242-244.
7.	Simpson RI, Ramsay MA, Millard MW, et al. Management of pulmonary alveolar proteinosis by repeated bronchoalveolar lavage. Proc (Bayl Univ Med Cent),2000，13:119-120.
8.	Seymour JF, Presneill JJ.Pulmonary alveolar proteinosis:progress in the first 44 years. Am J Respir Crit Care Med, 2002，166:215-235.

1. Trapnell BC, Whitsett JA, Nakata K. Pulmonary alveolar proteinosis. N Engl J Med,2003，349:2527-2539.
2. Beccaria M, Luisetti M, Rodi G,et al. Long-term durable benefit after whole lung lavage in pulmonary alveolar proteinosis.Eur Respir J,2004，23: 526-531.
3. Ramirez J, Schultz RB, Dutton RE. Pulmonary alveolar proteinosis: a new technique and rationale for treatment. Arch Intern Med,1963，112:419-431.
4. Goldstein LS, Kavuru MS, Curtis-McCarthy P, et al. Pulmonary alveolar proteinosis: clinical features and outcomes. Chest, 1998，114: 1357-1362.
5. Richard A.Morris Manual of Clinical problems in pulmonary medicine 5th ed .天津：天津科技翻译出版公司,2003.524.
6. 蔡后荣，崔苏阳，金陵，等.体外循环膜氧合支持下全肺灌洗治疗肺泡蛋白沉积症一例并文献复习.中华结核和呼吸杂志，2005，28：242-244.
7. Simpson RI, Ramsay MA, Millard MW, et al. Management of pulmonary alveolar proteinosis by repeated bronchoalveolar lavage. Proc (Bayl Univ Med Cent),2000，13:119-120.
8. Seymour JF, Presneill JJ.Pulmonary alveolar proteinosis:progress in the first 44 years. Am J Respir Crit Care Med, 2002，166:215-235.

Chinese Journal of Respiratory and Critical Care Medicine

再次全肺灌洗治疗肺泡蛋白沉积症一例

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