Objective  To explore the clinical significance of the platelet glycoproteins CD62p and CD63 in septic patients.Methods  The expressions of CD62p and CD63 in peripheral platelet were measured in 40 septic patients within 24 hours after onset by flow cytometry.The expression levels of CD62p and CD63 in mild and severe sepsis and normal subjects were compared.Meanwhile the correlation of CD62p and CD63 with APACHE Ⅱ score was analyzed.Results  Significant differences in the CD62p and CD63 levels were found in the septic patients when compared with the normal subjects [CD62p：（2.56±1.51）% vs （1.48±0.40）%；CD63：（2.15±0.50）% vs （1.29±0.35）%；all P lt;0.01].The expressions of CD62p and CD63 in the severe septic patients were significantly higher than those in the mild septic patients [CD62p：（3.31±1.94）% vs （2.05±0.87）%；CD63：（2.37±0.36）% vs （2.00±0.53）%；all P lt;0.05].The positive correlations of CD62p and CD63 with APACHE Ⅱ score were also found（CD62p：r=0.377，P=0.016；CD63：r=0.452，P=0.003）.Conclusion  Platelets were significantly activated in septic patients at early stage which was correlated with the severity of sepsis.

Citation： LIN Mengxiang,WEI Hongjian,CAI Helun. The clinical significance of platelet membrane glycoprotein CD62p and CD63 in patients with sepsis. Chinese Journal of Respiratory and Critical Care Medicine, 2007, 6(3): 205-207. doi: Copy