Changes of urotensin Ⅱ level in induced sputum of patients with asthma_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

WU Rui ¹ ,  CHEN Yahong ¹ , YAO Wanzhen ¹ , WANG PeiPei ¹ , GENG Bin ² , TANG Chaoshu ²

Department of Respiratory Medicine，Third Hospital，Beijing Medical University.Beijing，100083，ChinaCorresponding author：CHEN Ya-hong，E-mail：chenyahong@vip.sina.com;

Corresponding author：

CHEN Yahong, Email: chenyahong@vip.sina.com

Keywords：

Asthma; Urotensin Ⅱ; Induced sputum

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the role of urotensin Ⅱ(UⅡ) in the pathogenesis of asthma.Methods Lung function，differential cell count and level of UⅡin induced sputum were studied in 26 asthmatic patients in acute exacerbation and in clinical remission.Results Induced sputum UⅡ level from acute asthma was higher than that of remissed asthma [(58.88±47.38)pg/mL vs (12.69±12.78)pg/mL，P lt;0.01].Induced sputum UⅡ levels of asthma patients in acute exacerbation had a tendency to increase as disease deteriorated，which negatively correlated with FEV1% predicted (r=-0.326，P lt;0.05)，but did not with sputum total cell and neutrophil counts(P gt;0.05).No significant difference of induced sputum UⅡ levels was found between male and female，smokers and non-smokers.Conclusion UⅡ may play a role in acute exacerbation of asthma

Citation： WU Rui,CHEN Yahong,YAO Wanzhen,WANG PeiPei,GENG Bin,TANG Chaoshu. Changes of urotensin Ⅱ level in induced sputum of patients with asthma. Chinese Journal of Respiratory and Critical Care Medicine, 2008, 08(2): 128-131. doi: Copy

1.	Conlon JM，Yano K，Waugh D，et al.Distribution and molecular forms of urotensin Ⅱ and its role in cardiovascular regulation in vertebrates.J Exp Zool，1996，275：226-238.
2.	Coulouarn Y，Lihrmann I，Jegou S，et al.Cloning of Cdna encoding the urotensin Ⅱprecusor in frog and human reveals intense expression of the urotensin Ⅱgene in motoneurons of the spinal cord.Proc Natl Acad Sci USA，1998，95：15803-15808.
3.	陈亚红，赵鸣武，夏春芳，等.尾加压素在大鼠平滑肌细胞增殖中的作用及其机制.中华医学杂志，2000，80：928-930.
4.	李建东，于忠和，刘伯英，等.支气管哮喘患者血浆尾加压素Ⅱ、肾上腺髓质素水平的变化及其临床意义.中华结核和呼吸杂志，2003，26：797.
5.	张珺辉，张靖薄.尾加压素Ⅱ与支气管哮喘相关性的研究.中国临床医学，2004，11：971-973.
6.	中华医学会呼吸病学会哮喘学组.支气管哮喘防治指南（支气管哮喘的定义、诊断、治疗及教育和管理方案）.中华内科杂志，2003，42：817-822.
7.	Pavord ID，Pizzicbini M，Pizzicbini E，et al.The use of induced sputum to investigate airway inflammation.Thorax，1997，52：498-501.
8.	Takanobu Y，Mike M，Yukio H，et al.Role of urotensin Ⅱ in peripheral tissueasan autocrine/peracrine growth factor.Peptides，2004，25：1775-1781.
9.	石云，杜军保，曾超美，等.慢性低氧性肺动脉高压大鼠肺内肺动脉中尾加压素Ⅱ的变化.基础医学与临床，2002，22：78-83.
10.	路明，姚婉贞，陈亚红，等.尾加压素Ⅱ在慢性阻塞性肺病大鼠中的变化.基础医学与临床，2006，26：1063-1066.
11.	路明，姚婉贞，陈亚红，等.慢性阻塞性肺病患者血浆及诱导痰中尾加压素Ⅱ的变化及其意义.北京大学学报，2006，38：155-158.
12.	Tzanidis A，Hannan RD，Thomas WG，et al.Direct Actions of Urotensin Ⅱ on the Heart Implications for Cardiac Fibrosis and Hypertrophy.Circ Res，2003，93：246-253.
13.	Douglas SA，Tayara L，Ohlstein EH，et al.Congestive heart failure and expression of myocardial urotensin Ⅱ.Lancet，2002，359：1990-1997.
14.	刘伯英，于忠和，郝淑玲.低氧大鼠血浆和支气管肺泡灌洗液尾加压素Ⅱ的变化.第三军医大学学报，2004，26：1742-1744.
15.	龚永生，胡良冈，唐朝枢，等.慢性低氧对大鼠血浆尾加压素Ⅱ浓度和右心室尾加压素Ⅱ受体的影响.中国病理生理杂志，2003，19：704-705.

1. Conlon JM，Yano K，Waugh D，et al.Distribution and molecular forms of urotensin Ⅱ and its role in cardiovascular regulation in vertebrates.J Exp Zool，1996，275：226-238.
2. Coulouarn Y，Lihrmann I，Jegou S，et al.Cloning of Cdna encoding the urotensin Ⅱprecusor in frog and human reveals intense expression of the urotensin Ⅱgene in motoneurons of the spinal cord.Proc Natl Acad Sci USA，1998，95：15803-15808.
3. 陈亚红，赵鸣武，夏春芳，等.尾加压素在大鼠平滑肌细胞增殖中的作用及其机制.中华医学杂志，2000，80：928-930.
4. 李建东，于忠和，刘伯英，等.支气管哮喘患者血浆尾加压素Ⅱ、肾上腺髓质素水平的变化及其临床意义.中华结核和呼吸杂志，2003，26：797.
5. 张珺辉，张靖薄.尾加压素Ⅱ与支气管哮喘相关性的研究.中国临床医学，2004，11：971-973.
6. 中华医学会呼吸病学会哮喘学组.支气管哮喘防治指南（支气管哮喘的定义、诊断、治疗及教育和管理方案）.中华内科杂志，2003，42：817-822.
7. Pavord ID，Pizzicbini M，Pizzicbini E，et al.The use of induced sputum to investigate airway inflammation.Thorax，1997，52：498-501.
8. Takanobu Y，Mike M，Yukio H，et al.Role of urotensin Ⅱ in peripheral tissueasan autocrine/peracrine growth factor.Peptides，2004，25：1775-1781.
9. 石云，杜军保，曾超美，等.慢性低氧性肺动脉高压大鼠肺内肺动脉中尾加压素Ⅱ的变化.基础医学与临床，2002，22：78-83.
10. 路明，姚婉贞，陈亚红，等.尾加压素Ⅱ在慢性阻塞性肺病大鼠中的变化.基础医学与临床，2006，26：1063-1066.
11. 路明，姚婉贞，陈亚红，等.慢性阻塞性肺病患者血浆及诱导痰中尾加压素Ⅱ的变化及其意义.北京大学学报，2006，38：155-158.
12. Tzanidis A，Hannan RD，Thomas WG，et al.Direct Actions of Urotensin Ⅱ on the Heart Implications for Cardiac Fibrosis and Hypertrophy.Circ Res，2003，93：246-253.
13. Douglas SA，Tayara L，Ohlstein EH，et al.Congestive heart failure and expression of myocardial urotensin Ⅱ.Lancet，2002，359：1990-1997.
14. 刘伯英，于忠和，郝淑玲.低氧大鼠血浆和支气管肺泡灌洗液尾加压素Ⅱ的变化.第三军医大学学报，2004，26：1742-1744.
15. 龚永生，胡良冈，唐朝枢，等.慢性低氧对大鼠血浆尾加压素Ⅱ浓度和右心室尾加压素Ⅱ受体的影响.中国病理生理杂志，2003，19：704-705.

Previous Article
Evolution of Levels of Evidence and Strength of Recommendations in Medical Research
Next Article
Evidence-Based Treatment of a Patient with Follicular Lymphoma by Rituximab

Chinese Journal of Respiratory and Critical Care Medicine

Changes of urotensin Ⅱ level in induced sputum of patients with asthma

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content