Endotoxin absorption in the treatment of severe sepsis in the 2008 Wenchuan earthquake_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

ZHOU Yan , LIANG Peng , HUANG Kun , WU Xiaodong , KANG Yan

Intensive Care Unit,,West China Hospital,,Sichuan University. Chengdu,Sichuan, 610041, ChinaCorresponding author：KANG Yan ,E-mail: kangyan@medmail.com.cn;

Corresponding author：

Keywords：

Earthquake; Endotoxin; Adsorption; Sepsi

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Objective To observe the efficacy of endotoxin absorption for treatment of the 2008 Wenchuan ea~hquake victims with severe sepsis．Methods Two patients with severe sepsis was given endotoxin absorption with PMX treatment．Results Both patients recovered from near-fatal conditions．Conclusion PMX is a new effective approach for the treatment of patients with severe sepsis

Citation： ZHOU Yan,LIANG Peng,HUANG Kun,WU Xiaodong,KANG Yan. Endotoxin absorption in the treatment of severe sepsis in the 2008 Wenchuan earthquake. Chinese Journal of Respiratory and Critical Care Medicine, 2008, 08(4): 259-262. doi: Copy

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9.	Bellomo R,Tipping P,Boyce N.Continuous veno-venous hemofiltration with dialysis removes cytokines from the circulation of septic patients.Critical Care Med,1993,21:522.
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11.	Tsuzuki H,Tani T,Ueyama H,et al.Lipopolysaccharide:Neutralization by polymyxin B shuts down the signaling pathway of nuclear factor kappB in peripheral blood mononuclear cells,even during activation.Surg Res ,2001,100:127-134.
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13.	Sato T, Shoji H, Koga N. Endotoxin adsorption by polymyxinB immobilized fiber column in patients with systemic inflammatory response syndrome:the Japanese experience.Ther Apher Dial,2003,7:252-258.

1. O’Reilly M,Newcomb D E,Remck D ,et al.Endotoxin sepsis,and the primrose path.Shock,1999,12:411-420.
2. Kastow sky M，Gutberlet T，Bradaczek H.Molecular modelling of the three dimensional structure and conformational flexibility of bacterial lipopolysaccharide.Bacterial,1992,174:4798.
3. Raetz CRH.Biochemistry of endotoxins.Annu Rev Biochem，1990,59∶129.
4. Deitch EA .Multiple organ failure:pathophysiology and potential future therapy. Ann Surg,1992,216:117.
5. Deitch EA, Ma WJ, Ma L,et al.Endotoxin induced bacteria Translocation: a study of mechanism. Surgery,1989,106:292.
6. Cruz DN, Bellomo R, Ronco C.Clinical effects of polymyxin B immobilized fiber column in septic patients.Contrib Nephrol,2007,156:444-451.
7. Shoji H,Minaga M,Sakai Y,et al.Design and development of endotoxin detoxifying column PMX and its clinical application.Jpn Art Organs,1993,22:204.
8. Hanasawa K,Tani T,Kodama M.New approach to endotoxic and septic shock by means of polymyxin B immobilized fiber.Surg Gynecol Obstet,1989,168:323.
9. Bellomo R,Tipping P,Boyce N.Continuous veno-venous hemofiltration with dialysis removes cytokines from the circulation of septic patients.Critical Care Med,1993,21:522.
10. Andrew M,Calvin B.Reversal of postburn immunosuppression with low dose polymyxin B.Trauma,1986,26:995-998.
11. Tsuzuki H,Tani T,Ueyama H,et al.Lipopolysaccharide:Neutralization by polymyxin B shuts down the signaling pathway of nuclear factor kappB in peripheral blood mononuclear cells,even during activation.Surg Res ,2001,100:127-134.
12. Kodama M, Hanasawa K, Tani T.Blood purification for critical care medicine: endotoxin adsorption. Ther Apher,1997,1:224-227.
13. Sato T, Shoji H, Koga N. Endotoxin adsorption by polymyxinB immobilized fiber column in patients with systemic inflammatory response syndrome:the Japanese experience.Ther Apher Dial,2003,7:252-258.

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Chinese Journal of Respiratory and Critical Care Medicine

Endotoxin absorption in the treatment of severe sepsis in the 2008 Wenchuan earthquake

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